DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14238 and Y119C1B.3

DIOPT Version :9

Sequence 1:	NP_651480.1	Gene:	CG14238 / 43195	FlyBaseID:	FBgn0039429	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_491386.2	Gene:	Y119C1B.3 / 191027	WormBaseID:	WBGene00022469	Length:	450	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	145/509 - (28%)
Similarity:	233/509 - (45%)	Gaps:	104/509 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IISTIKAILTRIIFSAHSLLAIWQVVALKSDIIYWALCGPLLLLLLEGIFTIMIKKTQEWRWFCP 68
            :||.::|||.|.||..||::.|.|.|.:......|......||::.||.:.|:::...|.:|||.
Worm    30 LISCLRAILARGIFIVHSIVTIRQTVLISERESVWGFALLSLLIVFEGGYAIIMRAGDERKWFCT 94

  Fly    69 SVFLYLSSIVPAIWLLELDKVARRVGNMTSTNSTVYSPSNYSIPVGNTTIFITSTNSSGVPPVAT 133
            |||||:.:..|.||:||     .|:.|. .||                    ...|:.|...:
Worm    95 SVFLYIVATAPPIWILE-----TRICNW-RTN--------------------MEKNTEGFETL-- 131

  Fly   134 LLGQAGVTLSVTPDTWTTLIEQFLMLILIVGRWLLPKGDLTRDQLSQLLLVYIGTAADIIEFFDS 198
               |..|.|....:....|:||.|::.||||||||||||::|:||||:||.|:..::||:||||.
Worm   132 ---QHPVALKDNSELRLQLLEQLLLVNLIVGRWLLPKGDISREQLSQILLAYLAISSDIVEFFDV 193

  Fly   199 YKDDSIAKIGFLVFLTLGIWSWSLMQFTIVLSATRGRRPRGSGSHHKE-----EHTDCCQNCCCG 258
            :|:..:.....:..:.|..|:.||:||..||:.:|.|:.|.:.::..|     :....|......
Worm   194 FKEKVVYSNSRVQTIVLTAWTLSLLQFPFVLTVSRARKMRVAITNDYEQLFARQRPRSCFKAFYD 258

  Fly   259 IDVWGIVLNVILQDAPFLTFRLLIIFQYKIINYMNVFFTCKNSLVIILQLYRLYVVNAEFWKNRR 323
            :|:|.|.|..:|||.|||..||.::..:.:|.|..:||..||.|:|:||.||..::..:.:.|.:
Worm   259 VDIWAIFLANVLQDVPFLLVRLYLMTVHNLITYTMIFFFFKNMLIILLQTYRSIIIINDRYINPK 323

  Fly   324 ESRMAKSRQFQSRRKVQDADQNSIYMISNERGGDVKKKIKRAKDKDYAEQEAVYSK---KKKDKK 385
            ...|             |..::::.::.:.|..|:        |.||......:.|   |..:|.
Worm   324 PPDM-------------DIIEHNMDLMKSSRTNDI--------DDDYPSSPYSHHKTHNKHYEKM 367

  Fly   386 DKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNAD 450
            .||::||:......|::.:..:::.:|.:..        ||::|:.|::|:   ...||:|
Worm   368 SKKEKKREKKSKKAAAANHKNASRNNGNETP--------KKTRRSSSTTPT---RTPKQRR---- 417

  Fly   451 KNDKKKSRKIEAVVEESSSSSSSSSDSSNSTLPSYEVIDEKKARRRKHRGSSSD 504
                             ||...|.||......|            |.|.|...|
Worm   418 -----------------SSRIRSISDEREQLFP------------RHHHGRRLD 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14238	NP_651480.1	Tmem26	4..310	CDD:286813	108/310 (35%)
Y119C1B.3	NP_491386.2	Tmem26	30..310	CDD:286813	108/310 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166659
Domainoid	1	1.000	180	1.000	Domainoid score	I2094
eggNOG	1	0.900	-	-		E1_KOG4610
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137693
Inparanoid	1	1.050	197	1.000	Inparanoid score	I2503
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48045
OrthoDB	1	1.010	-	-		D1097257at2759
OrthoFinder	1	1.000	-	-		FOG0005371
OrthoInspector	1	1.000	-	-		oto20081
orthoMCL	1	0.900	-	-		OOG6_105455
Panther	1	1.100	-	-	LDO	PTHR22168
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4007
SonicParanoid	1	1.000	-	-		X3811
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800