DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and HKL3

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_195497.1	Gene:	HKL3 / 829940	AraportID:	AT4G37840	Length:	493	Species:	Arabidopsis thaliana

Alignment Length:	428	Identity:	115/428 - (26%)
Similarity:	207/428 - (48%)	Gaps:	29/428 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 LAKDTHARAVIKC------FVSHVQDLPTGKERGKYLALDLGGSNFRVLLVNLISN----SDVET 125
            |..|..|....:|      .||....||:|.|:|.:..::|.|....:|...|..|    |||:
plant    63 LVADMTASLTAECCGSLNMLVSFTGSLPSGDEKGVHYGVNLRGKELLLLRGTLGGNEEPISDVQ- 126

  Fly   126 MSKGYNFPQTLMSGSGKALFDFLAECLSEF--CHSHGLENESLALGFTFSFPLQQQGLSKGILVA 188
             ......|..:::||.|.|.||::..|.:|  .:..|...|...||||.:..::|.| |..|...
plant   127 -KHEIPIPDDVLNGSFKELCDFISLELVKFLAMNPGGEAEEVKNLGFTLTRSVEQIG-SHSISSI 189

  Fly   189 WTKGFSCEG--VVGKNVVSLLQEAIDRRG-DLKINTVAILNDTVGTLMSCAFYHPNCRIGLIVGT 250
            ..|..:.:.  .|.|::|:.:.|:::..| .:::|| |::::|:|.|....:||.:....:.:|.
plant   190 HRKSLANDDDEKVLKDLVNDMNESLETHGLKIRMNT-ALVDNTIGELAGGRYYHKDTVAAVSLGM 253

  Fly   251 GSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYDKAVDKVTPNPGKQTF 315
            |:||.|:|:......::.....|: .::::.|||.|..   .....|.:|.::|..:.|||.:.|
plant   254 GTNAAYIEQAQEISRWKSAIREPQ-EIVVSTEWGDFRS---CHLPITEFDASLDAESLNPGHRIF 314

  Fly   316 EKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVESDAPGEYRNCNKVLS 380
            ||.:||.|:||:||.|:..|..:..:|...:..|:...:...:..::.:..|...|....||.|.
plant   315 EKMVSGRYLGEIVRRVLLKMSEESALFGDTLPPKLTIPYILWSPDMAAMHQDISEERETVNKKLK 379

  Fly   381 EL-GILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNINEVAIGI---DGSVYRFHPKY 441
            |: ||:......:|.:..:|:.|:.|:|:|...|:|.:|.|:...|..:.|   :|.:|..:..:
plant   380 EVFGIMDSTLAAREVVVEVCDVVAERAARLAGAGIVGMIKKLGRLEKKMSIVIVEGGLYDHYRVF 444

  Fly   442 HDMLQYHMKKLLKPGVKFELVV--SEDGSGRGAALVAA 477
            .:.|...:.::|...:...:|:  |..||..||..:||
plant   445 RNYLHSSVWEMLGDELSDHVVIEHSHGGSAAGALFLAA 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	115/428 (27%)
		Hexokinase_1	41..237	CDD:278764	50/180 (28%)
		Hexokinase_2	243..477	CDD:281689	61/239 (26%)
HKL3	NP_195497.1	PLN02596	1..490	CDD:178206	115/428 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	128	1.000	Domainoid score	I1730
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.940