DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and HXK1

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_194642.1	Gene:	HXK1 / 829034	AraportID:	AT4G29130	Length:	496	Species:	Arabidopsis thaliana

Alignment Length:	473	Identity:	162/473 - (34%)
Similarity:	256/473 - (54%)	Gaps:	61/473 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AAVKGFLID----QEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALD 104
            |.:|.|..|    ..|:.:|.:.||.|:..|||.|..::  :|..:|:|.:||:|.|:|.:.|||
plant    39 AILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSK--LKMLISYVDNLPSGDEKGLFYALD 101

  Fly   105 LGGSNFRVLLVNL------ISNSDVETMSKGYNFPQTLMSGSGKALFDFLAECLSEF----CHS- 158
            |||:||||:.|.|      :...:.|.:|    .|..||:|....||:|:||.|::|    |..
plant   102 LGGTNFRVMRVLLGGKQERVVKQEFEEVS----IPPHLMTGGSDELFNFIAEALAKFVATECEDF 162

  Fly   159 HGLENESLALGFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRG-DLKINTV 222
            |..|.....||||||||::|..||.|.|:.||||||.|..||::||..|.:|::|.| |::|  .
plant   163 HLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRI--A 225

  Fly   223 AILNDTVGTLMSCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKP-SMIINCEWGAF 286
            |::|||||||....:|:|:....:|:|||:||.|||:......:.|  ..||. .|:||.|||.|
plant   226 ALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHG--LLPKSGEMVINMEWGNF 288

  Fly   287 GDNGVLEFVRTSYDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQ 351
            ..:   ....|.:|..:|..:.|||:|..||.|||||:||::|.|:..|......|...:..|::
plant   289 RSS---HLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLR 350

  Fly   352 ERWSFKTAYISDVESDAPGEYRNCNKVLSELGILGCQEPD-----------KEALRYICEAVSSR 405
            ..:..:|.::|.:.:|..          .:|.|:|.:..|           ::.:..:|..:::|
plant   351 IPFIIRTPHMSAMHNDTS----------PDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATR 405

  Fly   406 SAKLCACGLVTIINKM--------NINEVAIGIDGSVYRFHPKYHDMLQYHMKKLL--KPGVKFE 460
            .|:|.|.|:..|:.|:        .:.:..|.:||.::..:.::.:.::..:|:||  :.....|
plant   406 GARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVE 470

  Fly   461 LVVSEDGSGRGAALVAAT 478
            :..|.||||.||||:||:
plant   471 VTHSNDGSGIGAALLAAS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	162/473 (34%)
		Hexokinase_1	41..237	CDD:278764	87/208 (42%)
		Hexokinase_2	243..477	CDD:281689	71/255 (28%)
HXK1	NP_194642.1	PLN02405	1..496	CDD:215226	162/473 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840