DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and HXK2

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_179576.1	Gene:	HXK2 / 816505	AraportID:	AT2G19860	Length:	502	Species:	Arabidopsis thaliana

Alignment Length:	448	Identity:	157/448 - (35%)
Similarity:	250/448 - (55%)	Gaps:	31/448 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDLGGSNFRVLLVNLIS 119
            |:.:|.:.||.|:..|||.:..::  :|..:|:|.:||:|.|.|.:.||||||:||||:.|.|..
plant    54 KLRQVADAMTVEMHAGLASEGGSK--LKMLISYVDNLPSGDETGFFYALDLGGTNFRVMRVLLGG 116

  Fly   120 NSD--VETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLE-----NESLALGFTFSFPLQ 177
            ..|  |:...|..:.|..||:|....||||:.:.|::|..:.|.:     .....||||||||::
plant   117 KHDRVVKREFKEESIPPHLMTGKSHELFDFIVDVLAKFVATEGEDFHLPPGRQRELGFTFSFPVK 181

  Fly   178 QQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLMSCAFYHPNC 242
            |..||.|.|:.||||||.:..|.|:||..|.:|::|.| |.:...|::|||:|||....:.:|:.
plant   182 QLSLSSGTLINWTKGFSIDDTVDKDVVGELVKAMERVG-LDMLVAALVNDTIGTLAGGRYTNPDV 245

  Fly   243 RIGLIVGTGSNACYVEKTVNAECFEGYQTSPKP-SMIINCEWGAFGDNGVLEFVRTSYDKAVDKV 306
            .:.:|:|||:||.|||:......:.|  ..||. .|:||.|||.|..:   ....|.||.::|..
plant   246 VVAVILGTGTNAAYVERAHAIPKWHG--LLPKSGEMVINMEWGNFRSS---HLPLTEYDHSLDVD 305

  Fly   307 TPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVESDAPGE 371
            :.|||:|..||.|||||:||::|.|:..|..:...|..|:..|::..:..:|..:|.:.||...:
plant   306 SLNPGEQILEKIISGMYLGEILRRVLLKMAEEAAFFGDIVPPKLKIPFIIRTPNMSAMHSDTSPD 370

  Fly   372 YRNCNKVLSELGILGCQEPD---KEALRYICEAVSSRSAKLCACGLVTIINKM--------NINE 425
            .:.....|.:  ||..|...   ::.:..:|..::||.|:|.|.|:..|:.|:        ...:
plant   371 LKVVGSKLKD--ILEVQTSSLKMRKVVISLCNIIASRGARLSAAGIYGILKKIGRDATKDGEAQK 433

  Fly   426 VAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGV--KFELVVSEDGSGRGAALVAATAVQ 481
            ..|.:||.::..:.::.:.::..:|:||...|  ..|:::|.||||.||||:||:..|
plant   434 SVIAMDGGLFEHYTQFSESMKSSLKELLGDEVSESVEVILSNDGSGVGAALLAASHSQ 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	157/448 (35%)
		Hexokinase_1	41..237	CDD:278764	77/188 (41%)
		Hexokinase_2	243..477	CDD:281689	76/247 (31%)
HXK2	NP_179576.1	PLN02405	1..497	CDD:215226	157/448 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840