DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and Hex-A

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	430	Identity:	243/430 - (56%)
Similarity:	319/430 - (74%)	Gaps:	1/430 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDLGGSNFRVLL 114
            |:..|::.|:..|:..|::.|||||||.:|.:||||::|||||.|.||||:|||||||:||||||
  Fly   103 LLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKFLALDLGGTNFRVLL 167

  Fly   115 VNLISNSDVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLALGFTFSFPLQQQ 179
            ::|..|:|.:..|:.|..||.:|.|||..|||.:|||||.|...|.:..|.|.|||||||||:|.
  Fly   168 IHLQENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQL 232

  Fly   180 GLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLMSCAFYHPNCRI 244
            ||:||:|..|||||:|.|||.::||.||::||.||||::|:..||||||.|||||||:.:.||:|
  Fly   233 GLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAWKNHNCKI 297

  Fly   245 GLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYDKAVDKVTPN 309
            |||||||:||||:|:...||.|.. :...|..::||.|||||||||.|:||||.:|:.:|..:.|
  Fly   298 GLIVGTGANACYMERVEEAELFAA-EDPRKKHVLINTEWGAFGDNGALDFVRTEFDRDIDVHSIN 361

  Fly   310 PGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVESDAPGEYRN 374
            ||||||||.|||||||||||||:..|...|.:|:|..||.:..|..|.|.|:|::|:|.||.:.|
  Fly   362 PGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTKYVSEIEADEPGNFTN 426

  Fly   375 CNKVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNINEVAIGIDGSVYRFHP 439
            |..||.|||:....:.|...:|||||.||.|:|.|.:.|:.|:||||:...|.:|:|||||||||
  Fly   427 CRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINKMDEPTVTVGVDGSVYRFHP 491

  Fly   440 KYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATA 479
            |:|:::...:.:|:|||:.|:|::||||||||||||||.|
  Fly   492 KFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVA 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	243/430 (57%)
		Hexokinase_1	41..237	CDD:278764	110/186 (59%)
		Hexokinase_2	243..477	CDD:281689	127/233 (55%)
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	110/186 (59%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	128/234 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448962
Domainoid	1	1.000	138	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5026
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm6466
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	P	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
	12	11.800