DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and hk2

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_998231.1	Gene:	hk2 / 406339	ZFINID:	ZDB-GENE-040426-2017	Length:	919	Species:	Danio rerio

Alignment Length:	441	Identity:	187/441 - (42%)
Similarity:	281/441 - (63%)	Gaps:	14/441 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDLGGSNFRVLLV 115
            :.::::.||.:||.:|:|.||||.||..|.:|...:.|:..|.|.|||.:|||||||:|||||||
Zfish   481 LGRDQLLEVKKRMEEEMKRGLAKKTHNNATVKMLPTFVRSTPDGTERGDFLALDLGGTNFRVLLV 545

  Fly   116 NLISNS--DVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLALGFTFSFPLQQ 178
            .:....  :||..:|.|..||.:..|:|:.|||.:..|:::|....|::..||.||||||||..|
Zfish   546 RVRGGKRRNVEMNNKIYTIPQDITQGTGEELFDHIVHCIADFLEYMGMKGASLPLGFTFSFPCHQ 610

  Fly   179 QGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLMSCAFYHPNCR 243
            ..|.:|||:.|||||...|..|::|.|||::||.|..:..::.||::||||||:|:|.:..|.|.
Zfish   611 DKLDQGILIKWTKGFKASGCEGEDVASLLKDAIHRCEEFDLDVVAVVNDTVGTMMTCGYEDPQCE 675

  Fly   244 IGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYDKAVDKVTP 308
            :|||||||:||||:|:..|.|..:|    .:..|.:|.|||||||.|.|:.:.|.:|:|||..:.
Zfish   676 VGLIVGTGTNACYMEEMSNVELVDG----DEGRMCVNMEWGAFGDQGELDDIWTEFDRAVDDQST 736

  Fly   309 NPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVESDAPGEYR 373
            .||:|.:||.|||||:||:||.|:....|||.:|.|.:||:::.|..|:|.::|.:|||... .|
Zfish   737 YPGRQRYEKMISGMYLGEIVRNVLLHFTAKGLLFRGKLSERLKTRGIFETKFLSQIESDRLA-LR 800

  Fly   374 NCNKVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNIN------EVAIGIDG 432
            ....:|..||:......|...::.:|..||.|:|:||..||..:::|:.:|      .:.:|:||
Zfish   801 QVRSILQHLGLTSSTCDDSILVKEVCSVVSKRAAQLCGAGLAAVVDKIRLNRGLNQLSITVGVDG 865

  Fly   433 SVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATAVQAK 483
            ::|:.||.:..:::..::. |.|..:..||.||||||:||||:.|.|.:.:
Zfish   866 TLYKLHPHFATIMRETLRD-LAPNCEVSLVQSEDGSGKGAALITAVACRLR 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	187/439 (43%)
		Hexokinase_1	41..237	CDD:278764	87/187 (47%)
		Hexokinase_2	243..477	CDD:281689	96/239 (40%)
hk2	NP_998231.1	PTZ00107	12..462	CDD:240270
		Hexokinase_1	21..219	CDD:278764
		Hexokinase_2	225..461	CDD:281689
		Hexokinase_1	473..669	CDD:278764	87/187 (47%)
		COG5026	474..911	CDD:227359	186/435 (43%)
		Hexokinase_2	675..910	CDD:281689	96/240 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm6466
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.920