DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and hkdc1

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001108597.1	Gene:	hkdc1 / 321224	ZFINID:	ZDB-GENE-030131-9801	Length:	919	Species:	Danio rerio

Alignment Length:	452	Identity:	195/452 - (43%)
Similarity:	289/452 - (63%)	Gaps:	21/452 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EIEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDL 105
            ||:..:..|.:...::.||.::|..|::.||.|:||..|.:|...::|...|.|.||||||||||
Zfish   469 EIDDTLAAFALTSTQLQEVKQKMHVELERGLKKETHPTASVKMLPTYVYRTPDGTERGKYLALDL 533

  Fly   106 GGSNFRVLLVNL---ISNSDVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLA 167
            ||:|||||:|.:   :.|| |...:|.|..|..:|.|:|:.|||.:.:|:|:|....|::|..|.
Zfish   534 GGTNFRVLVVKIRTGMRNS-VRMYNKIYAIPLEIMQGTGEELFDHIVQCISDFLDYMGMKNTRLP 597

  Fly   168 LGFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTL 232
            ||||||||..|.|:.||.||.|||||......|.:||.:|:|||.||.:..::.|||:||||||:
Zfish   598 LGFTFSFPCNQTGIDKGDLVCWTKGFKATDCEGYDVVDMLREAIKRRNEFDLDIVAIVNDTVGTM 662

  Fly   233 MSCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRT 297
            |:||:..|.|:||||.|||||.||:|:..|.|..||    .:..|.:|.|||.||:|..:|.:||
Zfish   663 MTCAYEDPKCQIGLIAGTGSNVCYMEEMKNIEIVEG----DEGQMCVNTEWGGFGENDNIEDIRT 723

  Fly   298 SYDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYIS 362
            .||:.||..:.|.|||.|||..||||:||:||.::.|:..:||:|.|.|:|:::.:..|:|.::|
Zfish   724 RYDREVDSGSLNAGKQRFEKMTSGMYLGEIVRQILIDLTKRGFLFRGRITERLKTKGIFETKFLS 788

  Fly   363 DVESDAPGEYR-NCNKVLSELGI-LGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNIN- 424
            .:|||.....: .|  :|..||: ..|.  |...::.:|.|||.|:|:||..|:..|::|:..|
Zfish   789 QIESDRLALLQVRC--ILQSLGLDSTCD--DSIIVKEVCGAVSRRAAQLCGAGMAAIVDKIRENR 849

  Fly   425 -----EVAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATAVQ 481
                 ::.:|:||::|:.||.:..:|:..::: |.|..|.:.::||||||:||||:.|.|.|
Zfish   850 GLDRLDITVGVDGTLYKLHPHFSTILKETVRE-LAPNCKVDFILSEDGSGKGAALITAVARQ 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	195/452 (43%)
		Hexokinase_1	41..237	CDD:278764	92/198 (46%)
		Hexokinase_2	243..477	CDD:281689	97/241 (40%)
hkdc1	NP_001108597.1	Hexokinase_1	21..219	CDD:278764
		PTZ00107	29..460	CDD:240270
		Hexokinase_2	225..459	CDD:281689
		PTZ00107	462..908	CDD:240270	193/448 (43%)
		Hexokinase_1	469..667	CDD:278764	92/198 (46%)
		Hexokinase_2	673..907	CDD:281689	97/242 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2517
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm6466
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820