DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and HK1

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001309294.1	Gene:	HK1 / 3098	HGNCID:	4922	Length:	952	Species:	Homo sapiens

Alignment Length:	454	Identity:	199/454 - (43%)
Similarity:	288/454 - (63%)	Gaps:	17/454 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EIEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDL 105
            :||..:..|.:.::.:.||.:||..|:::||.|.||..||:|...|.|:..|.|.|.|.:|||||
Human   504 QIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDL 568

  Fly   106 GGSNFRVLLVNLISNS--DVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLAL 168
            ||:|||||||.:.|..  .||..:|.|..|..:|.|:|:.|||.:..|:|:|....|::...:.|
Human   569 GGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPL 633

  Fly   169 GFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLM 233
            |||||||.||..|..|||:.|||||.....||.:||:||::||.||.:..::.||::||||||:|
Human   634 GFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMM 698

  Fly   234 SCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTS 298
            :||:..|.|.:||||||||||||:|:..|.|..||.|    ..|.||.|||||||||.|:.:||.
Human   699 TCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQ----GQMCINMEWGAFGDNGCLDDIRTH 759

  Fly   299 YDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISD 363
            ||:.||:.:.|.|||.:||.|||||:||:||.::.|...|||:|.|.|||.::.|..|:|.::|.
Human   760 YDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQ 824

  Fly   364 VESDAPGEYRNCNKVLSELGILG-CQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNIN--- 424
            :|||... ......:|.:||:.. |.  |...::.:|..||.|:|:||..|:..:::|:..|
Human   825 IESDRLA-LLQVRAILQQLGLNSTCD--DSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGL 886

  Fly   425 ---EVAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATAVQAKSK 485
               .|.:|:||::|:.||.:..::...:|: |.|......::||||||:||||:.|..|:.:::
Human   887 DRLNVTVGVDGTLYKLHPHFSRIMHQTVKE-LSPKCNVSFLLSEDGSGKGAALITAVGVRLRTE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	199/450 (44%)
		Hexokinase_1	41..237	CDD:278764	91/197 (46%)
		Hexokinase_2	243..477	CDD:281689	103/240 (43%)
HK1	NP_001309294.1	PTZ00107	47..495	CDD:240270
		Hexokinase_1	56..254	CDD:278764
		Hexokinase_2	260..494	CDD:281689
		PTZ00107	497..942	CDD:240270	197/445 (44%)
		Hexokinase_1	504..702	CDD:278764	91/197 (46%)
		Hexokinase_2	708..942	CDD:281689	103/241 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2536
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100530
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm8559
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.820