DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-t2 and hxk2

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_593865.1	Gene:	hxk2 / 2543607	PomBaseID:	SPAC4F8.07c	Length:	455	Species:	Schizosaccharomyces pombe

Alignment Length:	471	Identity:	157/471 - (33%)
Similarity:	239/471 - (50%)	Gaps:	39/471 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VNTEIEAAVKGFLIDQEKMTEVVERMTKEI----KMGLAKDTHARAVIKCFVSHVQDLPTGKERG 98
            :....:.|||..:.|.|..||.:....||.    :.||.|:....|:...|:|   .||||.|.|
pombe     1 MEANFQQAVKKLVNDFEYPTESLREAVKEFDELRQKGLQKNGEVLAMAPAFIS---TLPTGAETG 62

  Fly    99 KYLALDLGGSNFRVLLVNLISNSDVETM-SKGYNFPQTLMSGSGKALFDFLAECLSEFCHSH--- 159
            .:||||.||:|.||..:.|:.:...|.. ||.....:.:.:.|.|.:.||:::.:..|...|
pombe    63 DFLALDFGGTNLRVCWIQLLGDGKYEMKHSKSVLPRECVRNESVKPIIDFMSDHVELFIKEHFPS 127

  Fly   160 --GL-ENESLALGFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINT 221
              |. |.|.|.:|||||:|..|..:::..|:.||||.:....:.|:....|.|....| :|.|..
pombe   128 KFGCPEEEYLPMGFTFSYPANQVSITESYLLRWTKGLNIPEAINKDFAQFLTEGFKAR-NLPIRI 191

  Fly   222 VAILNDTVGTLMSCAF--YHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWG 284
            .|::|||||||::.|:  ...:..:|:|.|||:|..|||:........|..|.  ..|:||.|||
pombe   192 EAVINDTVGTLVTRAYTSKESDTFMGIIFGTGTNGAYVEQMNQIPKLAGKCTG--DHMLINMEWG 254

  Fly   285 AFGDNGVLEFVRTSYDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFH-GIISE 348
            | .|...|.  .|.||..:|..|||.|:|.|||.:.|||:|||.|..:..:| |.:.|: ||...
pombe   255 A-TDFSCLH--STRYDLLLDHDTPNAGRQIFEKRVGGMYLGELFRRALFHLI-KVYNFNEGIFPP 315

  Fly   349 KIQERWSFKTAYISDVESDAPGEYRNCNKVLSELGILGCQEPDKEALRYI---CEAVSSRSAKLC 410
            .|.:.||.:|:.:|.:..:...|  |...|||.....  ...|:||| |:   ..|:..|:|::.
pombe   316 SITDAWSLETSVLSRMMVERSAE--NVRNVLSTFKFR--FRSDEEAL-YLWDAAHAIGRRAARMS 375

  Fly   411 ACGLVTIINKMNINEVA----IGIDGSVYRFHPKYHDMLQYHMKKLLKPGVK-FELVVSEDGSGR 470
            |..:.::.  ::.....    :|:|||:...:|.:.|||:..:::|:....| ..:.:::||||.
pombe   376 AVPIASLY--LSTGRAGKKSDVGVDGSLVEHYPHFVDMLREALRELIGDNEKLISIGIAKDGSGI 438

  Fly   471 GAALVAATAVQAKSKL 486
            ||||.|..||:.|..|
pombe   439 GAALCALQAVKEKKGL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	155/466 (33%)
		Hexokinase_1	41..237	CDD:278764	70/206 (34%)
		Hexokinase_2	243..477	CDD:281689	81/242 (33%)
hxk2	NP_593865.1	COG5026	1..454	CDD:227359	156/469 (33%)
		Hexokinase_1	8..207	CDD:278764	70/202 (35%)
		Hexokinase_2	216..445	CDD:281689	81/241 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56451
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	8	7.780