DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-t2 and hxk1

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_592948.1	Gene:	hxk1 / 2542634	PomBaseID:	SPAC24H6.04	Length:	484	Species:	Schizosaccharomyces pombe

Alignment Length:	460	Identity:	169/460 - (36%)
Similarity:	258/460 - (56%)	Gaps:	9/460 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GCNRKMPSLVNTEIEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPT 93
            |.|.|:...:...::...:.|.|..|.:..|.:|...|:..||..:.....::..::.   ..|.
pombe    18 GSNIKLNKTLQDHLDELEEQFTIPTELLHRVTDRFVSELYKGLTTNPGDVPMVPTWII---GTPD 79

  Fly    94 GKERGKYLALDLGGSNFRVLLVNLISNSDVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHS 158
            |.|.|.||||||||:|.||..|.:..|...:.....|..||.|..|:.:||||::|:|:.:|...
pombe    80 GNEHGSYLALDLGGTNLRVCAVEVQGNGKFDITQSKYRLPQELKVGTREALFDYIADCIKKFVEE 144

  Fly   159 -HGLENESLALGFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTV 222
             |..::::|.:|||||:|..|:.::...||||||||..:||.|::|..||..|:.|.|...:...
pombe   145 VHPGKSQNLEIGFTFSYPCVQRSINDASLVAWTKGFDIDGVEGESVGPLLSAALKRVGCNNVRLN 209

  Fly   223 AILNDTVGTLMSCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFG 287
            |||:||.|||::..:..|...||:|.|||.||||:||.........|......:|||||||..|
pombe   210 AILSDTTGTLVASNYASPGTEIGVIFGTGCNACYIEKFSEIPKLHKYDFPEDMNMIINCEWCDF- 273

  Fly   288 DNGVLEFVRTSYDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQE 352
            ||..:...||.||.|:|:.:|.||.||:||.|:|.|:|:::|.::.|:..:|.:|:|....||::
pombe   274 DNQHVVLPRTKYDVAIDEESPRPGLQTYEKMIAGCYLGDILRRILLDLYEQGALFNGQDVTKIRD 338

  Fly   353 RWSFKTAYISDVESDAPGEYRNCNKVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTI 417
            ..:..|:.:|.:|.|..........:..|...|...|.:::.:|..||.:.:|||:|.|||:..:
pombe   339 PLAMDTSVLSAIEVDPFENLDETQTLFEETYGLKTTEEERQFIRRACELIGTRSARLSACGVCAL 403

  Fly   418 INKMNINEVAIGIDGSVYRFHPKYHDMLQYHMKKLL--KPGVKFELVVSEDGSGRGAALVAATAV 480
            :.|||...:.:|.|||||..:|::.|.|....|.:|  :.|.|...:.:|||||.|||||  :|:
pombe   404 VRKMNKPSMIVGTDGSVYNLYPRFKDRLAQAFKDILGEEIGSKVVTIPAEDGSGVGAALV--SAL 466

  Fly   481 QAKSK 485
            :||.|
pombe   467 EAKGK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	165/454 (36%)
		Hexokinase_1	41..237	CDD:278764	71/196 (36%)
		Hexokinase_2	243..477	CDD:281689	90/235 (38%)
hxk1	NP_592948.1	COG5026	10..474	CDD:227359	169/460 (37%)
		Hexokinase_1	30..224	CDD:278764	71/196 (36%)
		Hexokinase_2	230..466	CDD:281689	90/238 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	169	1.000	Domainoid score	I906
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	302	1.000	Inparanoid score	I598
OMA	1	1.010	-	-		QHG56451
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		otm47135
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	13	12.830