DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hex-t2 and Hk3

DIOPT Version :9

Sequence 1:NP_733151.2 Gene:Hex-t2 / 43191 FlyBaseID:FBgn0042710 Length:486 Species:Drosophila melanogaster
Sequence 2:NP_071515.1 Gene:Hk3 / 25060 RGDID:2798 Length:924 Species:Rattus norvegicus


Alignment Length:444 Identity:186/444 - (41%)
Similarity:280/444 - (63%) Gaps:17/444 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 IEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDLG 106
            :|..:..|.:..|::|.|..:|.:.:..||..::.:   ::...::|:..|.|.|||.:||||||
  Rat   483 LEETLAPFQLSLEQLTAVQAQMREAMIRGLQGESSS---LRMLPTYVRATPDGSERGDFLALDLG 544

  Fly   107 GSNFRVLLVNLISNSDVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLALGFT 171
            |:|||||||. ::...|:..::.|:.|:.:..|||:.|||.:.:|:.:|....||..:||.||||
  Rat   545 GTNFRVLLVR-VAEGSVQITNQVYSIPEYVAQGSGQKLFDHIVDCIVDFQKRQGLSGQSLPLGFT 608

  Fly   172 FSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLMSCA 236
            ||||.:|.||.:|||:.|||||:..|..|::||.||:|||.||..:::|.|||:||||||:|||.
  Rat   609 FSFPCKQLGLDQGILLNWTKGFNASGCEGQDVVYLLREAIRRRQAVELNVVAIVNDTVGTMMSCG 673

  Fly   237 FYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYDK 301
            :..|.|.:|||||||:||||:|:..|.....|    ....|.||.|||||||:|.|..:.|.:|.
  Rat   674 YDDPCCEMGLIVGTGTNACYMEELRNVASVPG----DSGHMCINMEWGAFGDDGSLSMLGTCFDA 734

  Fly   302 AVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVES 366
            :||:.:.|||||.|||.|||||:||:||.::..:.:.|.:|.|..::.:|.|..|||.::|::||
  Rat   735 SVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQKTQCLQTRDIFKTKFLSEIES 799

  Fly   367 DAPGEYRNCNKVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNINE------ 425
            |:.. .|....:|.:|| |.....|...:..:|:|||.|:|:||..|:..::.|:..|.      
  Rat   800 DSLA-LRQVRAILEDLG-LTLTSDDALMVLEVCQAVSRRAAQLCGAGVAAVVEKIRENRGLQELT 862

  Fly   426 VAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATA 479
            |::|:||::|:.||.:..::...::| |.|......:.||||||:|||||...|
  Rat   863 VSVGVDGTLYKLHPHFSRLVSVTVRK-LAPQCTVTFLQSEDGSGKGAALVTRVA 915

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Hex-t2NP_733151.2 COG5026 31..483 CDD:227359 186/444 (42%)
Hexokinase_1 41..237 CDD:278764 86/194 (44%)
Hexokinase_2 243..477 CDD:281689 97/239 (41%)
Hk3NP_071515.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
PTZ00107 23..474 CDD:240270
Hexokinase_1 34..230 CDD:376323
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 84..220
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 95..104
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 185..186
Hexokinase large subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 221..460
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 221..222
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 304..307
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 426..428
Hexokinase_1 482..674 CDD:376323 86/194 (44%)
Hexokinase small subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 531..662 66/131 (50%)
Glucose-6-phosphate 2 binding. /evidence=ECO:0000250|UniProtKB:P19367 542..546 3/3 (100%)