DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and Hk1

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001380640.1	Gene:	Hk1 / 25058	RGDID:	2796	Length:	922	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	195/452 - (43%)
Similarity:	286/452 - (63%)	Gaps:	17/452 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EIEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDL 105
            :||..:..|.:.::.:.||.:|:..|::|||.|:|:::|.:|...|.|:.:|.|.|.|.:|||||
  Rat   473 QIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDL 537

  Fly   106 GGSNFRVLLVNLISNS--DVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLAL 168
            ||:|||||||.:.|..  .||..:|.|:.|..:|.|:|..|||.:..|:|:|....|::...:.|
  Rat   538 GGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPL 602

  Fly   169 GFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLM 233
            |||||||..|..|..|||::|||||......|.:|.|||::|:.||.:..::.||::||||||:|
  Rat   603 GFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMM 667

  Fly   234 SCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTS 298
            :||:..|.|.||||||||:||||:|:..|.|..||.|    ..|.||.|||||||||.|:.:||.
  Rat   668 TCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQ----GQMCINMEWGAFGDNGCLDDIRTD 728

  Fly   299 YDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISD 363
            :||.||:.:.|.|||.|||.|||||:||:||.::.|...|||:|.|.|||.::.|..|:|.::|.
  Rat   729 FDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQ 793

  Fly   364 VESDAPGEYRNCNKVLSELGILG-CQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNIN--- 424
            :|||... ......:|.:||:.. |.  |...::.:|..||.|:|:||..|:..::.|:..|
  Rat   794 IESDRLA-LLQVRAILQQLGLNSTCD--DSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGL 855

  Fly   425 ---EVAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATAVQAK 483
               .|.:|:||::|:.||.:..::...:|: |.|......::||||||:||||:.|..|:.:
  Rat   856 DHLNVTVGVDGTLYKLHPHFSRIMHQTVKE-LSPKCTVSFLLSEDGSGKGAALITAVGVRLR 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	195/450 (43%)
		Hexokinase_1	41..237	CDD:278764	86/197 (44%)
		Hexokinase_2	243..477	CDD:281689	104/240 (43%)
Hk1	NP_001380640.1	PTZ00107	23..464	CDD:240270
		Hexokinase_1	473..671	CDD:395278	86/197 (44%)
		Hexokinase_2	677..911	CDD:397683	104/241 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2383
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100530
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9035
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.920