DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hex-t2 and Hkdc1

DIOPT Version :9

Sequence 1:NP_733151.2 Gene:Hex-t2 / 43191 FlyBaseID:FBgn0042710 Length:486 Species:Drosophila melanogaster
Sequence 2:NP_663394.1 Gene:Hkdc1 / 216019 MGIID:2384910 Length:915 Species:Mus musculus


Alignment Length:445 Identity:187/445 - (42%)
Similarity:282/445 - (63%) Gaps:14/445 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 EIEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDL 105
            :|:..:..|.:.:|::..|.::|..|::.||.|.||:.|.:|...::|..:|.|.|:||:|||||
Mouse   469 QIDKVLALFQLTREQLLGVRDKMRAELEYGLKKKTHSLATVKMLPTYVYGMPDGTEKGKFLALDL 533

  Fly   106 GGSNFRVLLVNLISNSDVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLALGF 170
            ||:|||||||. |....|...:|.:..|..:|.|:|:.|||.:.:|:::|....||:...|.|||
Mouse   534 GGTNFRVLLVK-IRRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGAQLPLGF 597

  Fly   171 TFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLMSC 235
            |||||.:|..:.||.||.|||||......|::||.:|:|||.||.:..::.|||:||||||:|:|
Mouse   598 TFSFPCRQTCIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTC 662

  Fly   236 AFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYD 300
            .:..|.|.||||.|||||.||:|:..|.|..:|    .:..|.:|.|||.|||||.::.:||.||
Mouse   663 GYEDPRCEIGLIAGTGSNVCYMEEMRNIELVDG----DEGRMCVNTEWGGFGDNGCIDDIRTQYD 723

  Fly   301 KAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVE 365
            |.||:.:.|.|||.:||..||||:||:||.::.|:..:|.:|.|.|||:::.|..|:|.::|.:|
Mouse   724 KEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRGIFETKFLSQIE 788

  Fly   366 SDAPGEYRNCNKVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNINE----- 425
            ||... .....::|.:||:....| |...::.:|.|||.|:|::|..|:..|:.|...::     
Mouse   789 SDRLA-LLQVRRILQQLGLDSTCE-DSIVVKEVCGAVSRRAAQMCGAGMAAIVEKRREDQGLQHF 851

  Fly   426 -VAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATA 479
             |.:|:||::|:.||.:..:||..:|: |.|......::||||||:||||:.|.|
Mouse   852 KVTVGVDGTLYKLHPHFSRILQETVKE-LAPQCDVTFMLSEDGSGKGAALITAVA 905

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Hex-t2NP_733151.2 COG5026 31..483 CDD:227359 187/445 (42%)
Hexokinase_1 41..237 CDD:278764 86/195 (44%)
Hexokinase_2 243..477 CDD:281689 97/239 (41%)
Hkdc1NP_663394.1 Mitochondrial-binding peptide (MBP). /evidence=ECO:0000250|UniProtKB:Q2TB90 1..20
Hexokinase_1 21..219 CDD:376323
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 73..207
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 84..91
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 172..173
Hexokinase large subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 208..447
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 208..209
Hexokinase_2 225..459 CDD:377112
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 291..294
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 413..415
Hexokinase_1 469..664 CDD:376323 86/195 (44%)
Hexokinase small subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 521..652 62/131 (47%)
Glucose-6-phosphate 2 binding. /evidence=ECO:0000250|UniProtKB:P19367 532..536 3/3 (100%)