DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hex-t2 and Hk3

DIOPT Version :9

Sequence 1:NP_733151.2 Gene:Hex-t2 / 43191 FlyBaseID:FBgn0042710 Length:486 Species:Drosophila melanogaster
Sequence 2:NP_001028417.1 Gene:Hk3 / 212032 MGIID:2670962 Length:922 Species:Mus musculus


Alignment Length:489 Identity:198/489 - (40%)
Similarity:293/489 - (59%) Gaps:26/489 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RLL--THSLFGPVFKILFHNKTVCGGCNRKMPSLVNTE-------IEAAVKGFLIDQEKMTEVVE 61
            |:|  |.:|..|...:.|......||....|.:.|...       :|..:..|.:..|:||.|..
Mouse   436 RILKETVTLLAPNCDVSFIPSVDGGGRGVAMVTAVAARLAAHRRILEETLAPFQLTLEQMTVVQA 500

  Fly    62 RMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDLGGSNFRVLLVNLISNSDVETM 126
            :|.:.:..||..:..:   ::...::|:..|.|.|||.:|||||||:|||||||. ::...|:.:
Mouse   501 QMREAMIRGLQGEASS---LRMLPTYVRATPDGSERGDFLALDLGGTNFRVLLVR-VAEGSVQII 561

  Fly   127 SKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLALGFTFSFPLQQQGLSKGILVAWTK 191
            ::.|:.|:....|||:.|||.:.:|:.:|....||..:||.||||||||.:|.||.:|||:.|||
Mouse   562 NQVYSIPECRAQGSGQKLFDHIVDCIVDFQKRQGLSGQSLPLGFTFSFPCKQLGLDQGILLNWTK 626

  Fly   192 GFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLMSCAFYHPNCRIGLIVGTGSNACY 256
            ||:..|..|::||.||:|||.||..:::|.|||:||||||:|||.:..|.|.:|||||||:||||
Mouse   627 GFNASGCEGQDVVYLLREAIRRRQAVELNVVAIVNDTVGTMMSCGYDDPRCEMGLIVGTGTNACY 691

  Fly   257 VEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYDKAVDKVTPNPGKQTFEKCISG 321
            :|:..|.....|    ....|.||.|||||||:|.|..:.|.:|.:||:.:.|||||.|||.|||
Mouse   692 MEELRNVASVPG----DSGLMCINMEWGAFGDDGSLGTLSTRFDTSVDQASINPGKQRFEKMISG 752

  Fly   322 MYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVESDAPGEYRNCNKVLSELGILG 386
            ||:||:||.::..:...|.:|.|..::.:|.|..|||.::|::|||:.. .|....:|.:|| |.
Mouse   753 MYLGEIVRHILLHLTNLGVLFRGQKTQCLQARDIFKTKFLSEIESDSLA-LRQVRAILEDLG-LT 815

  Fly   387 CQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNINE------VAIGIDGSVYRFHPKYHDML 445
            ....|...:..:|:|||.|:|:||..|:..::.|:..|.      |::|:||::|:.||.:..::
Mouse   816 LTSDDALMVLEVCQAVSRRAAQLCGAGVAAVVEKIRENRGLQELTVSVGVDGTLYKLHPHFSKLV 880

  Fly   446 QYHMKKLLKPGVKFELVVSEDGSGRGAALVAATA 479
            ...::| |.|......:.||||||:|||||.|.|
Mouse   881 SATVRK-LAPQCTVTFLQSEDGSGKGAALVTAVA 913

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Hex-t2NP_733151.2 COG5026 31..483 CDD:227359 190/462 (41%)
Hexokinase_1 41..237 CDD:278764 87/202 (43%)
Hexokinase_2 243..477 CDD:281689 97/239 (41%)
Hk3NP_001028417.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Hexokinase_1 33..228 CDD:376323
PLN02914 70..469 CDD:178502 9/32 (28%)
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 82..218
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 93..102
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 183..184
Hexokinase large subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 219..458 6/21 (29%)
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 219..220
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 302..305
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 424..426
Hexokinase_1 480..672 CDD:376323 87/195 (45%)
Hexokinase small subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 529..660 66/131 (50%)
Glucose-6-phosphate 2 binding. /evidence=ECO:0000250|UniProtKB:P19367 540..544 3/3 (100%)