DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and Hex-t1

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	166/453 - (36%)
Similarity:	273/453 - (60%)	Gaps:	13/453 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KMPSLVNTEIEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKER 97
            |:..|.|..|:        |.||:...::|   ||.|||::|.|.|:.:.|.:|:|||||||:||
  Fly    16 KVCKLFNPSID--------DLEKIKNAMDR---EITMGLSRDHHDRSTVPCHLSYVQDLPTGRER 69

  Fly    98 GKYLALDLGGSNFRVLLVNLISNSDVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLE 162
            |::|||::..:|.|::||...|..|:.|.||....|.|:.:|.|..:|.|||..::.|.....::
  Fly    70 GQFLALEMMPTNCRIMLVKFSSERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVD 134

  Fly   163 NESLALGFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILND 227
            .::|.||..|:|.|::..|..||||:|||.|..:|.:||:||.||::|:.:..::.::.:.|:|.
  Fly   135 KDNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINV 199

  Fly   228 TVGTLMSCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVL 292
            ..|:|::..:..|:.|||||:|:.:|:||||:....|.:||.:.  :..||||.:|..|||.|.|
  Fly   200 GAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEY--RKLMIINSDWAHFGDTGQL 262

  Fly   293 EFVRTSYDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFK 357
            :|:|..||:.:|..:.|||.:.:||....:.||||||:::..::..|.:|.....:.|..:|...
  Fly   263 DFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQWKLD 327

  Fly   358 TAYISDVESDAPGEYRNCNKVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMN 422
            ...:.::.||.||.|....:|:.:..|..|:|.|..||:|||:.|::|:|.|.|.|:..:|::|.
  Fly   328 MVSLIEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMR 392

  Fly   423 INEVAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATAVQAKSK 485
            :.:::|.:||.:||.||.:..:|..:.:.|..|...||.|:::|..|.|||::|..|...|.|
  Fly   393 LPQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMAHANKYK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	164/449 (37%)
		Hexokinase_1	41..237	CDD:278764	73/195 (37%)
		Hexokinase_2	243..477	CDD:281689	85/233 (36%)
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	162/442 (37%)
		Hexokinase_1	13..209	CDD:278764	76/203 (37%)
		Hexokinase_2	215..448	CDD:281689	86/234 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448961
Domainoid	1	1.000	128	1.000	Domainoid score	I1730
eggNOG	1	0.900	-	-		E1_COG5026
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
	10	9.900