DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and LOC100492955

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_002936995.4	Gene:	LOC100492955 / 100492955	-ID:	-	Length:	728	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	167/456 - (36%)
Similarity:	264/456 - (57%)	Gaps:	27/456 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EIEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDL 105
            :||..:|...:.::.:.||..||.:|::.||.|:||..|.:|...:::...|||.|.|:::.|:|
Frog   283 KIENLLKPLQMSEKILQEVQARMRQEMERGLEKETHQCAFLKMLPTYICSKPTGNETGEFIVLEL 347

  Fly   106 GGSNFRVLLVNLISNSDVE--TMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLAL 168
            ||.|..::.|.:....:.|  .:.:.|..||.||.|:|:.|||.:|.||.:|...|.|....:.|
Frog   348 GGKNMHIVHVRIGGRPEEERSPIKETYTLPQNLMKGTGEELFDHIASCLLDFQKVHNLGGNKMYL 412

  Fly   169 GFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLM 233
            .|.|.||.:|..|::|.|:.|||||:..|...||||.||:.||.::.:|.:..:|::|||..|:|
Frog   413 SFVFPFPCKQTALNQGCLIKWTKGFAASGCEEKNVVELLERAIKQKRELNMTVIALVNDTTSTMM 477

  Fly   234 SCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTS 298
            :....|.:|.||||||||:||||:|:|.|.:.   ...:....|.:|.|||||||||.|:.:.|.
Frog   478 AGCSKHNSCEIGLIVGTGTNACYMEETKNIQM---EMENMSGQMCVNMEWGAFGDNGCLDDIITD 539

  Fly   299 YDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISD 363
            :|:.||..:.|||||.|||.|.|||:|::|..|:..:....|:...:  |..:.....|  ::..
Frog   540 FDQEVDVSSVNPGKQRFEKMIGGMYLGQIVHRVLIGLAHNDFLLSNL--EPRENLLELK--HLCL 600

  Fly   364 VESDAPG--EYRNCNKVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNIN-- 424
            :|.|...  |.|:   ||.:.| |.|...:.:.::.:|.|||:|:|:|||.|:..::.|:..|
Frog   601 IEGDKLSLVEVRS---VLLKCG-LNCALDEVKMVKIVCRAVSTRAAQLCAAGVAAVVEKIRENRA 661

  Fly   425 ----EVAIGIDGSVYRFHPKYHDMLQYHMKKLLKP--GVKFELVVSEDGSGRGAALVAATAVQAK 483
                ::|:|::|.:|..||.:.|.::..:|| |.|  .|.|   |..|..|:||||::|..:.|:
Frog   662 LDHLKIAVGVNGPLYEDHPNFKDEMESTLKK-LAPCCTVTF---VQSDSKGKGAALISAATINAQ 722

  Fly   484 S 484
            :
Frog   723 T 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	166/453 (37%)
		Hexokinase_1	41..237	CDD:278764	73/197 (37%)
		Hexokinase_2	243..477	CDD:281689	90/243 (37%)
LOC100492955	XP_002936995.4	Hexokinase_2	<195..274	CDD:397683
		Hexokinase_1	283..480	CDD:395278	73/196 (37%)
		Hexokinase_2	487..717	CDD:397683	90/244 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56451
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920