DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t2 and hk2

DIOPT Version :9

Sequence 1:	NP_733151.2	Gene:	Hex-t2 / 43191	FlyBaseID:	FBgn0042710	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001120545.1	Gene:	hk2 / 100145699	XenbaseID:	XB-GENE-5817381	Length:	915	Species:	Xenopus tropicalis

Alignment Length:	448	Identity:	197/448 - (43%)
Similarity:	288/448 - (64%)	Gaps:	17/448 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EIEAAVKGFLIDQEKMTEVVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDL 105
            :|:..:..|.:.|.|:.||..||..|:.:||.|||||.|.:|...::|:..|.|.|||.::||||
Frog   465 QIDEILAPFQLSQAKLEEVQSRMRTEMAIGLCKDTHASATVKMLPTYVRSTPDGTERGDFIALDL 529

  Fly   106 GGSNFRVLLVNLISNSD--VETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLAL 168
            ||:|||||.|::....|  |:.:||.|:.||.::.|:|..|||.:.:|:|||...:.|....|.|
Frog   530 GGTNFRVLYVHIGRREDVGVQIVSKTYSLPQEIIQGTGVKLFDHIIDCISEFQSENNLRGRRLPL 594

  Fly   169 GFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLM 233
            |||||||.:|..|.:|||:.||||||..|.|||:||.||:||..|:.:..:..||::||||||:|
Frog   595 GFTFSFPCKQTNLDQGILMTWTKGFSASGCVGKDVVMLLREAAVRKKNNDLIVVALVNDTVGTMM 659

  Fly   234 SCAFYHPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTS 298
            :|.:..|.|.||||||||:||||:|:..|.|..:|    .:..|.:|.||||||||..||.:.||
Frog   660 TCGYSDPACEIGLIVGTGTNACYMEELRNVELLDG----DEGKMCVNMEWGAFGDNNCLEDIATS 720

  Fly   299 YDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISD 363
            :|:.|||.:.|||||.:||.|||||:||:||.::..:..:..:|.|.|||:::.|..|.|.::|.
Frog   721 FDRDVDKFSINPGKQRYEKMISGMYLGEIVRQILIILTQRKILFGGNISERLKTRDIFPTRFLSL 785

  Fly   364 VESDAPGEYRNCNKVLSELGILG-CQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMNIN--- 424
            :|||..|..: ...:|::||:.. |.  |...::.:|..||.|:|:|||.|:..::.||..|
Frog   786 IESDTLGLVQ-VRSILTDLGLRSTCD--DTMLVKEVCTVVSRRAAQLCAAGIAAVVEKMRENRGL 847

  Fly   425 ---EVAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRGAALVAATA 479
               :|.:|:||::|:.||.:..:: :...|:|.|......:.|:||||:||||:.|.|
Frog   848 EQLKVTVGVDGTLYKLHPHFAGVV-HETVKVLAPRCDVTFLQSDDGSGKGAALITAVA 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t2	NP_733151.2	COG5026	31..483	CDD:227359	197/448 (44%)
		Hexokinase_1	41..237	CDD:278764	94/197 (48%)
		Hexokinase_2	243..477	CDD:281689	99/240 (41%)
hk2	NP_001120545.1	Hexokinase_1	19..215	CDD:278764
		PTZ00107	27..456	CDD:240270
		Hexokinase_2	221..455	CDD:281689
		PTZ00107	462..904	CDD:240270	196/446 (44%)
		Hexokinase_1	465..663	CDD:278764	94/197 (48%)
		Hexokinase_2	669..903	CDD:281689	99/241 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9451
Panther	1	1.100	-	-	O	PTHR19443
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.110