DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tx and TFAP4

DIOPT Version :9

Sequence 1:	NP_001287543.1	Gene:	tx / 43190	FlyBaseID:	FBgn0263118	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_003214.1	Gene:	TFAP4 / 7023	HGNCID:	11745	Length:	338	Species:	Homo sapiens

Alignment Length:	259	Identity:	59/259 - (22%)
Similarity:	98/259 - (37%)	Gaps:	73/259 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SRKNAPTKSKTKAPPLSKYRRKTANARERTRMREINTAFETLRHCVPEAIKGEDAANTNEKLTKI 140
            |..|.|...:|:.....:.||:.||:.||.||:.||..|::|:..:|.        ...|||:|.
Human    30 SLANIPLTPETQRDQERRIRREIANSNERRRMQSINAGFQSLKTLIPH--------TDGEKLSKA 86

  Fly   141 TTLRLAMKYITML----TDSIRDPSYESEFIGECLEESANREARV----------DLEANEEAE- 190
            ..|:...:||..|    |..::..:....||.| |..|:.:..|.          |:..:|:||
Human    87 AILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQE-LSGSSPKRRRAEDKDEGIGSPDIWEDEKAED 150

  Fly   191 -----VELPVPVAKK-------------------PAKTKGSGKKSSAASKRQSQKQAKIVPQ--- 228
                 :||...:.|:                   |.|.|...::   ...:|.|:|.:::.|
Human   151 LRREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQ---VQLQQQQEQVRLLHQEKL 212

  Fly   229 -----------IPPISSGESCYATSSIGSPASSAYASL-----SSSSNSHSSSSSPGLELDSLV 276
                       :||.:.............|..|.:.::     ||..||.|:|..   .||::|
Human   213 EREQQQLRTQLLPPPAPTHHPTVIVPAPPPPPSHHINVVTMGPSSVINSVSTSRQ---NLDTIV 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tx	NP_001287543.1	HLH	95..154	CDD:278439	21/62 (34%)
TFAP4	NP_003214.1	HLH	49..100	CDD:306515	20/58 (34%)
		Leucine-zipper 1	100..120		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..141		4/23 (17%)
		Leucine-zipper 2	151..179		3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..338
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910