DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tx and AgaP_AGAP003876

DIOPT Version :9

Sequence 1:	NP_001287543.1	Gene:	tx / 43190	FlyBaseID:	FBgn0263118	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	XP_310434.4	Gene:	AgaP_AGAP003876 / 3290921	VectorBaseID:	AGAP003876	Length:	443	Species:	Anopheles gambiae

Alignment Length:	470	Identity:	154/470 - (32%)
Similarity:	195/470 - (41%)	Gaps:	158/470 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SNTYELHNYADLNDMARATDSKDSRKRKTASARGEKYSLRQKRQKRGSNEDGESANLADFQLELD 67
            :|.:....|...:.|...:.|..|..:|     .|||||||::.:|.:             ||..
Mosquito    28 NNNHNESGYVGHHLMGDGSGSLVSEIKK-----DEKYSLRQRQSRRTT-------------LETA 74

  Fly    68 PIAEPASKS-----RKNAP-TKSKTKAPPLSKYRRKTANARERTRMREINTAFETLRHCVPEAIK 126
            .|::..:|:     .|.|| .|.|.||.|||||||||||||||:||||||:|||.||..||.|:.
Mosquito    75 TISKTTTKTTTTTKEKAAPKEKPKPKAAPLSKYRRKTANARERSRMREINSAFENLRRAVPVAVA 139

  Fly   127 G-------------EDAANTNEKLTKITTLRLAMKYITMLTDSIRDPSYESEFIGECLEESANRE 178
            |             ..:|.::||||||||||||||||.:|:|.|.......|         .|.|
Mosquito   140 GTSGTSSPVSSPQCSGSAASSEKLTKITTLRLAMKYIRILSDMIHGTPGTLE---------NNNE 195

  Fly   179 ARVDLEANEEAEVEL---------------------PVPVAKKPAKTKGSGKKSSAASKRQSQKQ 222
              :|:..:.|.|.|:                     ..| |..||:.....|..||:||..||:
Mosquito   196 --LDMVNHNEIEREVMQKGLLLLEGGYQMGGPGYVSSAP-AVSPARPAVDAKPLSASSKNHSQQ- 256

  Fly   223 AKIVPQIPPISSGESCYATSSIGSPASSAYASLSSSSNSHS---SSSSPGLELDSLVGLNG---- 280
                       ||.|  ::||..||.....|..::||||.|   :|:|......:..|.||
Mosquito   257 -----------SGTS--SSSSTSSPRKRTSAKKTTSSNSRSKKTTSTSNNTRSRAAAGTNGRKTI 308

  Fly   281 --ISALD-----------SLLLDT-----------------SDGDSL----SCLSPGYGSLLTGS 311
              .|||:           |||.|:                 ||.|||    .||||    |.|.:
Mosquito   309 ANSSALEKIDDNIQLTAPSLLSDSSRPDPLGMDVDLCTVLESDNDSLILSEPCLSP----LTTAT 369

  Fly   312 GESLLPG--------CRGD---LPMSGLEKSDVELSLRLLDQSSKDSFDFASDQQPSACISSFSA 365
            |    ||        |...   :|..|||       ..|...|..||.     |....|:|..|.
Mosquito   370 G----PGGLKSHNFACTNSQSVVPNDGLE-------FGLFLGSDADSL-----QLSEPCLSPLSH 418

  Fly   366 LDGY-PF-DLLHSDF 378
            ||.. || ||||:.|
Mosquito   419 LDSLNPFNDLLHTGF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tx	NP_001287543.1	HLH	95..154	CDD:278439	42/71 (59%)
AgaP_AGAP003876	XP_310434.4	HLH	108..179	CDD:278439	42/70 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I15921
eggNOG	1	0.900	-	-		E1_KOG4395
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I7111
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto106301
Panther	1	1.100	-	-	LDO	PTHR19290
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X15359
TreeFam	1	0.960	-	-
	8	8.010