DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tx and Tcf4

DIOPT Version :9

Sequence 1:	NP_001287543.1	Gene:	tx / 43190	FlyBaseID:	FBgn0263118	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001348056.1	Gene:	Tcf4 / 21413	MGIID:	98506	Length:	670	Species:	Mus musculus

Alignment Length:	187	Identity:	46/187 - (24%)
Similarity:	68/187 - (36%)	Gaps:	49/187 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSKDSRKRKTASARGEKYSLRQKRQKRGSNEDGESANLADFQLELDPIAEPASKSRKNAPTKSKT 86
            |:|.|..:|...   :|..::...:.|.||.|.|...             |..|:.:
Mouse   524 DTKSSEDKKLDD---DKKDIKSITRSRSSNNDDEDLT-------------PEQKAER-------- 564

  Fly    87 KAPPLSKYRRKTANARERTRMREINTAFETLRHCVPEAIKGEDAANTNEKLTKITTLRLAMKYIT 151
                 .|.||...|||||.|:|:||.||:.|...|...:|      :::..||:..|..|:..|.
Mouse   565 -----EKERRMANNARERLRVRDINEAFKELGRMVQLHLK------SDKPQTKLLILHQAVAVIL 618

  Fly   152 MLTDSIRDPSYESEFIGECLEESANREARVDLEANEEAEVELPVPVAKKPAKTKGSG 208
            .|...:|             |.:.|.:|.. |:..||.:|....|.........|.|
Mouse   619 SLEQQVR-------------ERNLNPKAAC-LKRREEEKVSSEPPPLSLAGPHPGMG 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tx	NP_001287543.1	HLH	95..154	CDD:278439	21/58 (36%)
Tcf4	NP_001348056.1	Essential for MYOD1 inhibition	1..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..244
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..320
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..378
		Leucine-zipper	378..399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..426
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..573		15/77 (19%)
		bHLH_E-protein_TCF4_E2-2	561..645	CDD:381515	31/116 (27%)
		Class A specific domain	622..645		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..670		6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910