DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tx and MESP2

DIOPT Version :9

Sequence 1:	NP_001287543.1	Gene:	tx / 43190	FlyBaseID:	FBgn0263118	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001035047.1	Gene:	MESP2 / 145873	HGNCID:	29659	Length:	397	Species:	Homo sapiens

Alignment Length:	284	Identity:	73/284 - (25%)
Similarity:	106/284 - (37%)	Gaps:	89/284 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 PIAEPASKSRK----NAPTKSKTKAPPLSKYRRKTANARERTRMREINTAFETLRHCVPEAIKGE 128
            |..:|.|.|.:    .|.|..:.:..|... :|::|:.||:.|||.:..|...||..:|.::
Human    52 PQPQPPSCSSRAAEAAATTPRRARTGPAGG-QRQSASEREKLRMRTLARALHELRRFLPPSL--- 112

  Fly   129 DAANTNEKLTKITTLRLAMKYITMLTDSIRDPSYESEFIGECLEES--ANREARVD--------- 182
              |...:.||||.|||||::||..|          |..:| ..|||  ..|..|.|
Human   113 --APAGQSLTKIETLRLAIRYIGHL----------SAVLG-LSEESLQCRRRQRGDAGSPWGCPL 164

  Fly   183 ------LEANEEAEVELPVPVAKKPAKTKGSGK-KSSAASKRQSQKQAKIVPQIPPISSGESCYA 240
                  .||..:||           .:.:|.|: :.....:.|.|.|.:...:.|.:.|  :..|
Human   165 CPDRGPAEAQTQAE-----------GQGQGQGQGQGQGQGQGQGQGQGQGQGRRPGLVS--AVLA 216

  Fly   241 TSSIGSPASSAYASLSSSSNSHSSSSSPGLELDSLVGLNGISALDSLLLDTSDGDSLS----C-- 299
            .:|.|||                 |:.||.:          :|.:.|.....|.|..:    |
Human   217 EASWGSP-----------------SACPGAQ----------AAPERLGRGVHDTDPWATPPYCPK 254

  Fly   300 -LSPGYGSLLTGSGESLL---PGC 319
             .||.|.|..|.|..||.   .||
Human   255 IQSPPYSSQGTTSDASLWTPPQGC 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tx	NP_001287543.1	HLH	95..154	CDD:278439	23/58 (40%)
MESP2	NP_001035047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..92		11/40 (28%)
		HLH	82..135	CDD:278439	23/57 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..208		11/66 (17%)
		13 X 2 AA tandem repeats of G-Q	179..204		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..295		20/84 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870