Protein Alignment MMP10 and Mmp2

DIOPT Version :10

• Sequence 1: NP_002416.1
• Gene: MMP10 / 4319
• HGNCID: 7156
• Length: 476
• Species: Homo sapiens
• Sequence 2: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 679
• Identity: 178/679 - (26%)
• Similarity: 256/679 - (37%)
• Gaps: 249/679 - (36%)

Human    30 NKDLAQQYLEKYYNLEK-DVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGV 93
            ::|:...||.::..|.| |::....:..:.:.:.|:.:|.|..:.|||::|:.|..:::||||||
  Fly    46 SEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGV 110

Human    94 PDVGHFSSF--------------------PGMPKWRKTHLTYRIVNYT-PDLPRDAVDSAIEKAL 137
            .|.....||                    .| |||.:|.||:.:||.: ||..:  |:..::.||
  Fly   111 GDRRSADSFSPDNLYHEIGSNVRVRRFALQG-PKWSRTDLTWSMVNRSMPDASK--VERMVQTAL 172

Human   138 KVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKW 202
            .||...:.|||..:|..:|||.|.||.:.|||.|.|||||..||||:.||.|..||.|||.||.|
  Fly   173 DVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW 237

Human   203 -----TEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLY 262
                 ::|:.|||...||.|||||||||.|||..:|:|:|.|.: .|:|. .|..||..|||.||
  Fly   238 NFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQN-NEVAG-NLPDDDRYGIQQLY 300

Human   263 G----------PPPAST------------------------------------------------ 269
            |          |...:|
  Fly   301 GTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQE 365

Human   270 ----------------------------------------------------------------- 269
                                                                             
  Fly   366 KERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRP 430

Human   270 ----------------------------------------------EEPLVPTKSV---PSGSEM 285
                                                          .||:.||.:.   |:....
  Fly   431 RERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPY 495

Human   286 PA--------------KCDPALS-FDAISTLRGEYLFFKDRYFWR--------------RSHWNP 321
            |.              |.|..:: :||||.:|||...|:..|.||              |.||:.
  Fly   496 PTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSA 560

Human   322 EPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRK 386
            .||         :| :.:||.||...|..|| |.|.|::......:..|:|:.:.:||.|||:..
  Fly   561 LPE---------NL-TKVDAVYENKQRQIVF-FIGREYYVFNSVMLAPGFPKPLASLGLPPTLTH 614

Human   387 IDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAF-GFFYFFS 450
            |||:.......:||..:...|||.|:.:..:|..:||.:: .:.||...:||..|.. |..|||.
  Fly   615 IDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMS-IWSGVGYNIDAAFQYLDGKTYFFK 678

Human   451 GSSQFEFDPNARMVTHI---LKSNSWLHC 476
            ....:||:.:...|.|.   |.:..|:.|
  Fly   679 NLGYWEFNDDRMKVAHARAKLSARRWMQC 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MMP10	NP_002416.1	PG_binding_1	33..86	CDD:460223	13/53 (25%)
		Cysteine switch. /evidence=ECO:0000250	89..96		5/6 (83%)
		Peptidase_M10	107..263	CDD:425668	79/161 (49%)
		HX	286..476	CDD:238046	64/222 (29%)
		Hemopexin 1	286..335		19/77 (25%)
		Hemopexin 2	336..382		14/45 (31%)
		Hemopexin 3	384..432		12/47 (26%)
		Hemopexin 4	433..476		13/46 (28%)
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	13/50 (26%)
		Peptidase_M10	143..301	CDD:425668	79/161 (49%)
		HX	513..707	CDD:238046	62/205 (30%)