Protein Alignment ppk15 and Asic5

DIOPT Version :10

• Sequence 1: NP_001097937.1
• Gene: ppk15 / 43188
• FlyBaseID: FBgn0039424
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_071563.1
• Gene: Asic5 / 63866
• RGDID: 69295
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 558
• Identity: 118/558 - (21%)
• Similarity: 200/558 - (35%)
• Gaps: 179/558 - (32%)

  Fly     1 MGGTENAKGQV-------LRK---KRGFGFVTNIK----DYCTNCTLAGFAYIANSRLHFMERIF 51
            |..||.:||..       :|:   ||.....|:.|    |:..:.:..|...||.:: :.:.::.
  Rat     1 MEHTEKSKGPAEKGLLGKIRRYLSKRPLPSPTDRKKFDHDFAISTSFHGIHNIAQNQ-NKVRKVI 64

  Fly    52 WLICVFMS-SLGCYQL---IMGYQRSFPTRAVSIVYESLPPFSKWKFPAVSVCELAYRGNLFPKF 112
            ||..|..| ||..:|:   ::.|.....|.::.:.|     ..|.:||||:.|.|    |.|.
  Rat    65 WLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQY-----VEKIEFPAVTFCNL----NRFQ-- 118

  Fly   113 EEYITSLGVDVTGDYPYDVETGVSILLFPALYNENGLKGKCGTV--HKNCT-------------- 161
            .|.::..|:..   :.:|:.:.| :.|.....|..|.......|  |:|.:
  Rat   119 TEAVSRFGIIF---FLWDIVSKV-LRLQEISGNNTGSPEALDFVASHRNFSITEFVKNNGFYLNH 179

  Fly   162 DACAKCPSDNYRQILTWYGANCSDLFVECKLSHEPFDCCRHFLPLLTPFGRCYMLNSLLNNEPGS 226
            |....|         .::|..|           :|.|    |..:.|.:|.|:..|...|.:..:
  Rat   180 DTLVHC---------EFFGKTC-----------DPKD----FKHVFTEYGNCFTFNYGENVQSKN 220

  Fly   227 KHWLPNELDPAHQKAVINVITR-LDVQISVINAE--DIPHTAFFPPGIPLITEGLSKYMQFNQVA 288
            |               ::|..| |.:.:.|...|  |.|...|...|:..:.....|..||:.:.
  Rat   221 K---------------VSVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLG 270

  Fly   289 MKN-------------------------DPDVKDIDPKIRSCFFPEEIPADSLYKSYSFSVCITE 328
            :.:                         :||:     |:|:            :.:||...|:.|
  Rat   271 LSSPVGMHARVTIRQLKTIHQEYPWGECNPDI-----KLRN------------FTTYSTYGCLKE 318

  Fly   329 CIRRLQMKACNCTSFLYNPNADPRYPDCDLEGFLCLEKTRMIKPDSRVLVN-NNKG------NNA 386
            |..:...:.|.|..||...|.    .:|||     |:....:.|   :|.: ..||      :|:
  Rat   319 CKAKHIQRLCGCLPFLLPGNG----VECDL-----LKYYNCVSP---ILDHIERKGLCTMGTHNS 371

  Fly   387 SCGCLPSCNDGD--ITTIYEPLLFVR----------NPNKYYNGTL--------DMPFLPTDQYR 431
            ||. :| |.:.:  .|..|......|          ...:|....|        |:.:..|.|.:
  Rat   372 SCP-VP-CEETEYPATIAYSTFPSQRATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQK 434

  Fly   432 RQSLRTPLDVVVSMGGMLGLFLGASILSAIEFV-YYFT 468
            ..|:.   :::..:||.||||.|||:::.||.: |.||
  Rat   435 AVSVP---ELLADVGGQLGLFCGASLITIIEIIEYLFT 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:459966	104/514 (20%)
Asic5	NP_071563.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000269|PubMed:27679529	1..30		8/28 (29%)
		ASC	41..466	CDD:459966	104/513 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)