Protein Alignment ppk15 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_001097937.1
• Gene: ppk15 / 43188
• FlyBaseID: FBgn0039424
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 116/581 - (19%)
• Similarity: 181/581 - (31%)
• Gaps: 195/581 - (33%)

  Fly    27 YCTNCTLAGFAYIANSRLHFMERIFW----LICVFMSSLGCYQLIMGYQRSFPTRAVSIVYESLP 87
            ||.|....|...|..||.. :.|:.|    |..|.:....|..|:.    ||.|.:|||...
Human    32 YCLNTNTHGCRRIVVSRGR-LRRLLWIGFTLTAVALILWQCALLVF----SFYTVSVSIKVH--- 88

  Fly    88 PFSKWKFPAVSVCEL-AYR--------GNLFPKFEEYITSLGVDVTGDYPY-------DVETGVS 136
             |.|..||||::|.: .|:        .:|..:..|.:.||       |.:       :.|:..|
Human    89 -FRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSL-------YGFPESRKRREAESWNS 145

  Fly   137 IL---------LFPALYNENGLKGKC-------------GTVHK-------------------NC 160
            :.         ..|.|..:...|||.             ..:||                   |.
Human   146 VSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSND 210

  Fly   161 TDACAKCP-SDNYRQILTWY-------------------GANCSDLFVECKLSHEPFDCCRHFLP 205
            |..||... |.....|..||                   ..:..:|.|.|.......| .|:|..
Human   211 TSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCD-ARNFTL 274

  Fly   206 LLTPF-GRCYMLNS------LLNNEPGSKHWLPNELDPAHQKAVINVITRLDVQISVINAEDIPH 263
            ...|. |.||..|:      |..:..||::.|.                    .|..||.|:...
Human   275 FHHPMHGNCYTFNNRENETILSTSMGGSEYGLQ--------------------VILYINEEEYNP 319

  Fly   264 TAFFPPGIPLITEGLSKYMQFNQVAMKNDPDVKDIDPKIRSCFFP-------------------- 308
            ......|..:|.....:|           |.|:|:..:|.:....
Human   320 FLVSSTGAKVIIHRQDEY-----------PFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCT 373

  Fly   309 ---EEIPADSLYK-SYSFSVCITECIRRLQMKACNCTSFLYNPNADPRYPDCDLE----GFLCLE 365
               .::|..::|. :||..:|:..|.:...::.|.|..  |:....|....|:.:    ...|..
Human   374 EDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQ--YSQPLPPAANYCNYQQHPNWMYCYY 436

  Fly   366 KTRMIKPDSRVLVNNNKGNNASCGCLPSCNDGDITT--------IYEPLLFV-------RNPNKY 415
            :..      |..|....|..:.|....|..:..:||        :.|..|..       |..||.
Human   437 QLH------RAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKK 495

  Fly   416 YNGTLDMPFL---PTDQYRRQSLRTP---LDVVVS-MGGMLGLFLGASILSAIEFVYYFTV 469
            .|.| |:..|   ..|..:|..:.:|   :::::| .||.|||::..|::..||.:..|.:
Human   496 LNKT-DLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFI 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:279230	115/576 (20%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	116/581 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820