Protein Alignment ppk15 and SCNN1D

DIOPT Version :10

• Sequence 1: NP_001097937.1
• Gene: ppk15 / 43188
• FlyBaseID: FBgn0039424
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 114/562 - (20%)
• Similarity: 198/562 - (35%)
• Gaps: 164/562 - (29%)

  Fly    27 YCTNCTLAGFAYIANSRLHFMERIFWLICVFMSSLG-----CYQLIMGYQRSF--PT-RAVSIVY 83
            :|||.|:.|...:..||.:.::...|    .:.|||     |:||.:.::|.:  |. .|||:..
Human   227 FCTNATIHGAIRLVCSRGNRLKTTSW----GLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHS 287

  Fly    84 ESLPPFSKWKFPAVSVCELAYRGN------------LFPKF-EEYITSL-GVDVT---------- 124
            |      :...|.|::|:    ||            |..:| .|.|.|| .|:::
Human   288 E------RKLLPLVTLCD----GNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATV 342

  Fly   125 --GDYPYDVE----------TGVSILLFPALYNENGLKGKC-------GTV------HKNCTDAC 164
              .:.|:.::          :|..:.:...|.|..|  |.|       |..      |.:..|..
Human   343 PRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG--GDCFYRGYTSGVAAVQDWYHFHYVDIL 405

  Fly   165 AKCPSDNYRQILTW---YGANCSDLFVECKLSHEPFDC-CRHFLPLLTP-FGRCYMLNSLLN-NE 223
            |..|:       .|   :|:......:.|  |::..|| .|.|.....| :|.||.::.:.. ..
Human   406 ALLPA-------AWEDSHGSQDGHFVLSC--SYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQR 461

  Fly   224 PGSKHWLPNELDPAHQKAVINVITRLDVQISVINAEDIP----HTAFFPPGIPLITEGLSKYMQF 284
            ||..|.:...|....|..:..:.|...:::.|......|    |:....||    ||.
Human   462 PGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPG----TEA------- 515

  Fly   285 NQVAMKNDPDVKDIDPKIRSCFF-PEEIPADSLYK-SYSFSVCITECIRRLQMKACNCTSFLY-- 345
             .::::.| :|..:......|.. .|.:..:.|:. ||:...|:..|.::|.::.|:|..:|:
Human   516 -TISIRED-EVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPL 578

  Fly   346 -------NPNADPRYPDC------DLEGFLCLEKTRMIKPDSRVLVNNNKGNNASCGCLPSCNDG 397
                   :....|.:..|      |||.......:|..:|........:.|.:.    .||....
Human   579 PAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSR----WPSAKSA 639

  Fly   398 DITTIYEPLLFVRNPNKYYNGTLDMPFLPTDQYRRQSLRTPLDVVV------------------- 443
            ..|.                .||....||...:|::|....:::|.
Human   640 GWTL----------------ATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQL 688

  Fly   444 --SMGGMLGLFLGASILSAIEFV-YYFTVRPLSNMLGARAAR 482
              :||.:..|:.|||:||.:|.: .......|:.:||.|..|
Human   689 LSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLR 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:459966	109/544 (20%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211
		ENaC	219..784	CDD:273304	114/562 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777