Protein Alignment ppk15 and ASIC5

DIOPT Version :10

• Sequence 1: NP_001097937.1
• Gene: ppk15 / 43188
• FlyBaseID: FBgn0039424
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 110/503 - (21%)
• Similarity: 181/503 - (35%)
• Gaps: 133/503 - (26%)

  Fly    26 DYCTNCTLAGFAYIANSRLHFMERIFWLICVFMS-SLGCYQL---IMGYQRSFPTRAVSIVYESL 86
            |:..:.:..|...|..:|.. :.|:.||:.|..| ||..:|:   ::.|.....|.::.:.|
Human    40 DFAISTSFHGIHNIVQNRSK-IRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQY--- 100

  Fly    87 PPFSKWKFPAVSVCEL-AYRGNLFPKFEEYITSLGVDVTGDYPYDVETGVSILLF----PALYNE 146
              ..|.:||||:.|.| .::.:...||                     ||...|:    ..|:.:
Human   101 --VEKMEFPAVTFCNLNRFQTDAVAKF---------------------GVIFFLWHIVSKVLHLQ 142

  Fly   147 NGLKGKCGTVHKNCTDACAKCPSDNYRQILTWYG--ANCSDLFVECKLSHEPFDCC-RHFLPLLT 208
            .......|:  :..||..|...:.:..:.:...|  .|.|.| ::|:...:|  |. :.|..:.|
Human   143 EITANSTGS--REATDFAASHQNFSIVEFIRNKGFYLNNSTL-LDCEFFGKP--CSPKDFAHVFT 202

  Fly   209 PFGRCYMLNSLLNNEPGSKHWLPNELDPAHQKAVINVITRLDVQISVINAE---DIPHTAFFPPG 270
            .:|.|:..|          |.     :....|..::|..|....:..:|.|   |.|...|...|
Human   203 EYGNCFTFN----------HG-----ETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAG 252

  Fly   271 IPLITEGLSKYMQF------NQVAMKNDPDVKDIDPKIRSCFFPEEIPADSL--YKSYSFSVCIT 327
            |..:.....|..||      :.|.|.....::.:....:...:.|..|...|  :.|||.|.|:.
Human   253 IIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNFSSYSTSGCLK 317

  Fly   328 ECIRRLQMKACNCTSFLYNPNADPRYP-DCDLEGF---------------LCLEKTRMIKPDSRV 376
            ||..:...|.|.|..||.     |.|. :|||:.:               ||...|
Human   318 ECKAQHIKKQCGCVPFLL-----PGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGT--------- 368

  Fly   377 LVNNNKGNNASCGCLPSCNDGDITTIYEPLLF------------VRNPNKYYNGTL--------D 421
                   :|:||..  ||.:.:.........|            :....||....|        |
Human   369 -------HNSSCPV--SCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSD 424

  Fly   422 MPFLPTDQYRRQSLRTPLDVVVSMGGMLGLFLGASILSAIEFV-YYFT 468
            :.:..|.|.:..|:.   :::..:||.||||.|||:::.||.: |.||
Human   425 LNYKITQQQKAVSVS---ELLADLGGQLGLFCGASLITIIEIIEYLFT 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:459966	106/498 (21%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	106/497 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)