Protein Alignment ppk15 and ASIC1

DIOPT Version :10

• Sequence 1: NP_001097937.1
• Gene: ppk15 / 43188
• FlyBaseID: FBgn0039424
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 118/558 - (21%)
• Similarity: 193/558 - (34%)
• Gaps: 179/558 - (32%)

  Fly    23 NIKDYCTNCTLAGFAYIANSRLHFMERIFWLICVFMSSLG-----CYQLIMGYQRSFPTRAVSIV 82
            :|:.:.::.||.|.|:|.:.....::|..|.:| |:.||.     |.:.:..|   |....|:.:
Human    17 SIQAFASSSTLHGLAHIFSYERLSLKRALWALC-FLGSLAVLLCVCTERVQYY---FHYHHVTKL 77

  Fly    83 YESLPPFSKWKFPAVSVCEL-AYRGNLFPKFEEYITSLGVDVTGDYPYDV-------ETGVSILL 139
            .|...  |:..||||::|.| .:|.:...|.:.|.....:.:..: .|::       |..:.||.
Human    78 DEVAA--SQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN-RYEIPDTQMADEKQLEILQ 139

  Fly   140 FPALYNENGLKGKCGTVHKNCTDACAKCPSDNYRQILTWYGANCSDLFVECKLSHEPFDCC--RH 202
            ..|  |....|.|                ..|.|:.....|.:..|:.:.|   |...:.|  ..
Human   140 DKA--NFRSFKPK----------------PFNMREFYDRAGHDIRDMLLSC---HFRGEVCSAED 183

  Fly   203 FLPLLTPFGRCYMLNSLLNNEPGSK-------------------HWLP--NELDPAHQKAVINVI 246
            |..:.|.:|:||..||..:..|..|                   .:||  .|.|....:|.|.
Human   184 FKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIK-- 246

  Fly   247 TRLDVQISVINAEDIPHTAFFPPGIPLITEGLSKYMQFNQVAMKNDPDVKDIDPKIRSCFFPEEI 311
                |||         |:...||.|..:..|::...| ..||.:....:. :.|...:|   :.:
Human   247 ----VQI---------HSQDEPPFIDQLGFGVAPGFQ-TFVACQEQRLIY-LPPPWGTC---KAV 293

  Fly   312 PADS---LYKSYSFSVCITECIRRLQMKACNCTSFLYNPNADP-----RYPDCDLEGFLCLEKTR 368
            ..||   .:.|||.:.|..:|..|..::.||| ..::.|...|     :|.:|
Human   294 TMDSDLDFFDSYSITACRIDCETRYLVENCNC-RMVHMPGDAPYCTPEQYKEC------------ 345

  Fly   369 MIKPDSRVLVNNNKGNNASCGCLPSCNDGDITTIYEPLLFVRNPNKYYNGTLDMPFLPTDQYRRQ 433
             ..|....||..::   ..|.|...||   :|...:.|..|:.|:|.....|...|..::||..:
Human   346 -ADPALDFLVEKDQ---EYCVCEMPCN---LTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGE 403

  Fly   434 S-------------------------------LRTPLD--------------------------- 440
            :                               |.||:.
Human   404 NILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPP 468

  Fly   441 --------VVVSMGGMLGLFLGASILSAIE-FVYYFTV 469
                    .:..:||.:|||:|||||:.:| |.|.:.|
Human   469 QRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEV 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:459966	115/549 (21%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	117/556 (21%)