DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk15 and asic1b

DIOPT Version :9

Sequence 1:	NP_001097937.1	Gene:	ppk15 / 43188	FlyBaseID:	FBgn0039424	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	330	Identity:	81/330 - (24%)
Similarity:	127/330 - (38%)	Gaps:	83/330 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 DLFVECKLSHEPFDC-CRHFLPLLTPFGRCYMLNS-------LLNNEPGSKHWLPNELDPAHQKA 241
            |:.:||..:.:  :| ..|:..:.|.:|:||..||       |:..:.|..:.|...|| ..|..
Zfish   202 DMLLECNFAGK--ECGAEHWREIFTRYGKCYTFNSGQDGRPLLITTKGGMGNGLEIMLD-IQQDE 263

  Fly   242 VINVITRLD---------VQISVINAEDIPHTAFFPPGIPLITEGLSKYMQFNQVAMKNDPDVKD 297
            .:.|....|         |||         ||...||.|..:..|::.  .|.......:..:..
Zfish   264 YLPVWGETDETTFEAGIKVQI---------HTQDEPPFIDQLGFGVAP--GFQTFVSCQEQRLTY 317

  Fly   298 IDPKIRSCFFPEEIPADS-LYKSYSFSVCITECIRRLQMKACNCTSFLYNPNADP-----RYPDC 356
            :.|....|   :..|.|| .:.:||.:.|..:|..|..::.||| ..::.|...|     :|.:|
Zfish   318 LPPPWGDC---KATPIDSDFFNTYSITACRIDCETRYLVENCNC-RMVHMPGDAPYCTPEQYKEC 378

  Fly   357 DLEGFLCLEKTRMIKPDSRVLVNNNKGNNASCGCLPSCNDGDITTIYEPLLFVRNPNKYYNGTLD 421
                         ..|....||..   :|..|.|...||   :|...:.|.|||.|:|.....|.
Zfish   379 -------------ADPALDFLVER---DNDYCVCETPCN---MTRYGKELSFVRIPSKASAKYLA 424

  Fly   422 MPFLPTDQYRRQSLRTPLDV---------------------VVSMGGMLGLFLGASILSAIE-FV 464
            ..:..|:||...::.. ||:                     :..:||.:|||:|||||:.:| |.
Zfish   425 KKYNKTEQYISDNIMV-LDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILELFD 488

  Fly   465 YYFTV 469
            |.:.|
Zfish   489 YLYEV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:279230	79/325 (24%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57
		ASC	66..548	CDD:295594	81/330 (25%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020