Protein Alignment ppk15 and ASIC2

DIOPT Version :9

• Sequence 1: NP_001097937.1
• Gene: ppk15 / 43188
• FlyBaseID: FBgn0039424
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 115/551 - (20%)
• Similarity: 186/551 - (33%)
• Gaps: 198/551 - (35%)

  Fly    24 IKDYCTNCTLAGFAYIANSRLHFMERIFWLICVFMSSLGCYQLIMG-------YQRSFP--TRAV 79
            ::..|...|.||.:        |..|..|:: .|.:|.|   |::.       |..|||  ||..
Human    69 LRHMCAGRTAAGGS--------FQRRALWVL-AFCTSFG---LLLSWSSNRLLYWLSFPSHTRVH 121

  Fly    80 SIVYESLPPFSKWKFPAVSVC-------------ELAYRGN----LFPK--FEEYITSLGVDVTG 125
            ......||      ||||:||             :|.|.|:    |.|.  ....::.|   :.|
Human   122 REWSRQLP------FPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSEL---LRG 177

  Fly   126 DYP--------YDVETGVSILLFPALYNENGLKGKCGTVHKNCTDACAKCPSDNYRQILTWYGAN 182
            |.|        .|..     |..|..:.| |:..                      ..:...|..
Human   178 DEPRRQWFRKLADFR-----LFLPPRHFE-GISA----------------------AFMDRLGHQ 214

  Fly   183 CSDLFVECKLSHEPFDCCRH-FLPLLTPFGRCYMLNSLLNNEPGSKHWLPNELDPAHQKAVINVI 246
            ..|:.:.||...|.  |..| |..:.|.:|:|||.||   .|.|              |.::..:
Human   215 LEDMLLSCKYRGEL--CGPHNFSSVFTKYGKCYMFNS---GEDG--------------KPLLTTV 260

  Fly   247 -----TRLDVQISVINAEDIP------------------HTAFFPPGIPLITEGLSKYMQFNQVA 288
                 ..|::.:.:...|.:|                  |:...||.|..:..|::.  .|....
Human   261 KGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAP--GFQTFV 323

  Fly   289 MKNDPDVKDIDPKIRSC--------FFPEEIPADSLYKSYSFSVCITECIRRLQMKACNCTSFLY 345
            ...:..:..:.|....|        |||          .||.:.|..:|..|..::.||| ..::
Human   324 ATQEQRLTYLPPPWGECRSSEMGLDFFP----------VYSITACRIDCETRYIVENCNC-RMVH 377

  Fly   346 NPNADP-----RYPDCDLEGFLCLEKTRMIKPDSRVLVNNNKGNNASCGCLPSCNDGDITTIYEP 405
            .|...|     ::.:|             .:|...:|.  .|.:| .|.|...||   :|...:.
Human   378 MPGDAPFCTPEQHKEC-------------AEPALGLLA--EKDSN-YCLCRTPCN---LTRYNKE 423

  Fly   406 LLFVRNPNKYYNGTLDMPFLPTDQYRRQSLRTPLDV---------------------VVSMGGML 449
            |..|:.|:|.....|:..|..:::|..:::.. ||:                     :..:||.:
Human   424 LSMVKIPSKTSAKYLEKKFNKSEKYISENILV-LDIFFEALNYETIEQKKAYEVAALLGDIGGQM 487

  Fly   450 GLFLGASILSAIE---FVYYFTVRPLSNMLG 477
            |||:|||||:.:|   ::|......|.::||
Human   488 GLFIGASILTILELFDYIYELIKEKLLDLLG 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:279230	111/535 (21%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	115/551 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920