DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk15 and Asic2

DIOPT Version :9

Sequence 1:	NP_001097937.1	Gene:	ppk15 / 43188	FlyBaseID:	FBgn0039424	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_037024.2	Gene:	Asic2 / 25364	RGDID:	2017	Length:	563	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	115/551 - (20%)
Similarity:	187/551 - (33%)	Gaps:	198/551 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IKDYCTNCTLAGFAYIANSRLHFMERIFWLICVFMSSLGCYQLIMG-------YQRSFP--TRAV 79
            ::..|...|.||.:        |..|..|:: .|.:|||   |::.       |..|||  ||..
  Rat    69 LRHMCAGRTAAGGS--------FQRRALWVL-AFCTSLG---LLLSWSSNRLLYWLSFPSHTRVH 121

  Fly    80 SIVYESLPPFSKWKFPAVSVC-------------ELAYRGN----LFPK--FEEYITSLGVDVTG 125
            ......||      ||||:||             :|.|.|:    |.|.  ....::.|   :.|
  Rat   122 REWSRQLP------FPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSEL---LRG 177

  Fly   126 DYP--------YDVETGVSILLFPALYNENGLKGKCGTVHKNCTDACAKCPSDNYRQILTWYGAN 182
            |.|        .|..     |..|..:.| |:..                      ..:...|..
  Rat   178 DEPRRQWFRKLADFR-----LFLPPRHFE-GISA----------------------AFMDRLGHQ 214

  Fly   183 CSDLFVECKLSHEPFDCCRH-FLPLLTPFGRCYMLNSLLNNEPGSKHWLPNELDPAHQKAVINVI 246
            ..|:.:.||...|.  |..| |..:.|.:|:|||.||   .|.|              |.::..:
  Rat   215 LEDMLLSCKYRGEL--CGPHNFSSVFTKYGKCYMFNS---GEDG--------------KPLLTTV 260

  Fly   247 -----TRLDVQISVINAEDIP------------------HTAFFPPGIPLITEGLSKYMQFNQVA 288
                 ..|::.:.:...|.:|                  |:...||.|..:..|::.  .|....
  Rat   261 KGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAP--GFQTFV 323

  Fly   289 MKNDPDVKDIDPKIRSC--------FFPEEIPADSLYKSYSFSVCITECIRRLQMKACNCTSFLY 345
            ...:..:..:.|....|        |||          .||.:.|..:|..|..::.||| ..::
  Rat   324 ATQEQRLTYLPPPWGECRSSEMGLDFFP----------VYSITACRIDCETRYIVENCNC-RMVH 377

  Fly   346 NPNADP-----RYPDCDLEGFLCLEKTRMIKPDSRVLVNNNKGNNASCGCLPSCNDGDITTIYEP 405
            .|...|     ::.:|             .:|...:|.  .|.:| .|.|...||   :|...:.
  Rat   378 MPGDAPFCTPEQHKEC-------------AEPALGLLA--EKDSN-YCLCRTPCN---LTRYNKE 423

  Fly   406 LLFVRNPNKYYNGTLDMPFLPTDQYRRQSLRTPLDV---------------------VVSMGGML 449
            |..|:.|:|.....|:..|..:::|..:::.. ||:                     :..:||.:
  Rat   424 LSMVKIPSKTSAKYLEKKFNKSEKYISENILV-LDIFFEALNYETIEQKKAYEVAALLGDIGGQM 487

  Fly   450 GLFLGASILSAIE---FVYYFTVRPLSNMLG 477
            |||:|||:|:.:|   ::|......|.::||
  Rat   488 GLFIGASLLTILELFDYIYELIKEKLLDLLG 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:279230	111/535 (21%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	115/551 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020