Protein Alignment ppk15 and Scnn1b

DIOPT Version :10

• Sequence 1: NP_001097937.1
• Gene: ppk15 / 43188
• FlyBaseID: FBgn0039424
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_035455.1
• Gene: Scnn1b / 20277
• MGIID: 104696
• Length: 638
• Species: Mus musculus
• Alignment Length: 623
• Identity: 116/623 - (18%)
• Similarity: 205/623 - (32%)
• Gaps: 222/623 - (35%)

  Fly    12 LRKKRGFGFVTNIKDYCTNCTLAGFAYIANSRLHFMERI----------FWLICVFMSSLGCYQ- 65
            |:|..|:.:...:..||.           |:..|..:||          ::|:.:..:.|.|:|
Mouse    14 LQKGPGYTYKELLVWYCN-----------NTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQW 67

  Fly    66 --LIMGYQRSFPTRAVSIVYESLPPFSKWKFPAVSVC---------------------ELAYRGN 107
              .|..|.....:.::|:.::::      .||||:||                     |......
Mouse    68 GVFIQTYLSWEVSVSLSMGFKTM------NFPAVTVCNSSPFQYSKVKHLLKDLDELMEAVLEKI 126

  Fly   108 LFPKFEEYITSLGVDVT--------------GDYPYDVETGVSILLFPALYN-ENGLKGK----- 152
            |.|:.....|:..::.|              .|:|      |.:.||...:| .|...|.
Mouse   127 LAPEASHSNTTRTLNFTIWNHTPLVLIDERNPDHP------VVLNLFGDSHNSSNPAPGSTCNAQ 185

  Fly   153 -CGTVHKNCTDACAKCPSDNY----RQILTWYGANCSDLF-------------------VECKLS 193
             |....:.|:.....|...|:    :.:..||....:::|                   :.|...
Mouse   186 GCKVAMRLCSANGTVCTLRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFG 250

  Fly   194 HEPFDCCRH--FLPLLTP-FGRCYMLN------SLLNNEPGSKHWLPNELDPAHQKAVINVITRL 249
            .||   |.|  |.|:..| :|.||:.|      :|.:..||::..|...||...:..|..:.:..
Mouse   251 TEP---CSHRNFTPIFYPDYGNCYIFNWGMTEETLPSANPGTEFGLKLILDIGQEDYVPFLASTA 312

  Fly   250 DVQISV--------INAEDIPHTAFFPPGIPLITEGLSKYMQFNQVAMKNDP----DVKDIDPKI 302
            ..::.:        |..|.|...|.....|.::.:.|.:         |.:|    .:...|..|
Mouse   313 GARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQR---------KGEPYSPCTMNGSDVAI 368

  Fly   303 RSCFFPEEIPADSLYK-SYSFSVCITECIRRLQMKACNCTSFLYNPNADPRYPDCDLEGF----L 362
            ::.:        |:|. :||...|:..|.:...::.|:|..:||......:|  |:...|    .
Mouse   369 KNLY--------SVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYPLPEGEKY--CNNRDFPDWAY 423

  Fly   363 CLEKTRMIKPDSRVLVNNNKGNNASCGCLPSCNDGDITTIYEPLLFVRNPNKYYNGTLDMPFLPT 427
            |....:|........::.         |..||||                 ..|..|:.|...|:
Mouse   424 CYLNLQMSVTQRETCLSM---------CKESCND-----------------TQYKMTISMADWPS 462

  Fly   428 D-----------QYRRQS---------------------LRT----PLDVVV----SMGGMLGLF 452
            :           |.|.||                     .||    |.:.:|    ::||..|.:
Mouse   463 EASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFW 527

  Fly   453 LGASILSAIE-------FVYYFTVRPLSNMLGARAARP 483
            :|.|:|..||       |::...::.:::..|.|..||
Mouse   528 MGGSVLCLIEFGEIIIDFIWITIIKLVASCKGLRRRRP 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk15	NP_001097937.1	ASC	27..466	CDD:459966	109/589 (19%)
Scnn1b	NP_035455.1	ENaC	21..621	CDD:273304	113/616 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..620
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51168	614..618