DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and ABCB14

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_174122.1	Gene:	ABCB14 / 839694	AraportID:	AT1G28010	Length:	1247	Species:	Arabidopsis thaliana

Alignment Length:	754	Identity:	148/754 - (19%)
Similarity:	253/754 - (33%)	Gaps:	234/754 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRI 127
            ||:|.:.|:.|:..|..:..:|.||.||:|::|.:.......||||.:.|....:........::
plant   386 PNMVFENLSFTIHSGKTFAFVGPSGSGKSTIISMVQRFYEPRSGEILLDGNDIKNLKLKWLREQM 450

  Fly   128 GYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLPNASKFVKN---------- 182
            |.:.||.||:.      |.|...|:....|.:::.    :::.....||..|:|:
plant   451 GLVSQEPALFA------TTIASNILLGKEKANMDQ----IIEAAKAANADSFIKSLPNGYNTQVG 505

  Fly   183 -----LSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHY 242
                 |||||::|:::|.|:|..|::|:|||.|..:| ...:.|....:|......||::| .|.
plant   506 EGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALD-AESEKIVQQALDNVMEKRTTIVI-AHR 568

  Fly   243 IDECAQAHMIGLLRGGKM--------LAEESPDY----------------------LRQQYNADS 277
            :........|.:||.|::        |.....||                      .|.|..:.|
plant   569 LSTIRNVDKIVVLRDGQVRETGSHSELISRGGDYATLVNCQDTEPQENLRSVMYESCRSQAGSYS 633

  Fly   278 LEDVFLKLSVLQNMGKRRRSSIAQEIVEQVTVPAISNPALDMSDEQHAAEISGEFGDNISMSSAA 342
            ...||         ..||.||..::                  .|:...:..||  |.||.||..
plant   634 SRRVF---------SSRRTSSFRED------------------QEKTEKDSKGE--DLISSSSMI 669

  Fly   343 RDPISTTAPAAPPLPPPQEIPTSFWYNLHVMQSHHLHALIWKNFLWMMRNVGVM-------LFIV 400
            .:.|...||.              |          |:||        :.::|.:       ||.:
plant   670 WELIKLNAPE--------------W----------LYAL--------LGSIGAVLAGSQPALFSM 702

  Fly   401 GLPVVQILLFCYAIGHDPTGLKLAVANHEMSGEMIMEQFCPVHTGCNQTMLSCRYLDMLVKNKSM 465
            ||..|....:    ...|:.:|..|           ::...:..|..           :|.....
plant   703 GLAYVLTTFY----SPFPSLIKREV-----------DKVAIIFVGAG-----------IVTAPIY 741

  Fly   466 VVQ---YVTDDEMAYEEVRKGRAWAALV-------IQPNYTASLMERVEDGRYAEDGTIESSDLA 520
            ::|   |....|.....||.....|.|.       :..|.|.||...:     |.|.|:..|.:|
plant   742 ILQHYFYTLMGERLTSRVRLSLFSAILSNEIGWFDLDENNTGSLTSIL-----AADATLVRSAIA 801

  Fly   521 VRMDWSNQQISQLLYRDLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQHPVYGYRNPNFTDFAAPG 585
            .|:....|.:| |....|...||                           |.:|         ..
plant   802 DRLSTIVQNLS-LTITALALAFF---------------------------YSWR---------VA 829

  Fly   586 VILTIIFFLAVAVTSGAMLIDRNEG-----------MLERCLVAGITGPEILLS--QVVTQFTVM 637
            .::|..|.|.:|.:....|..:..|           .|.|..::.|.......:  |:..|||..
plant   830 AVVTACFPLLIAASLTEQLFLKGFGGDYTRAYSRATSLAREAISNIRTVAAFSAEKQISEQFTCE 894

  Fly   638 LSQTTFVLIVSFYFFELTLVGNIWLVVALCILNGLCGMSFG-FVISCAVDTERTATYVAMGSFLP 701
            ||:.|...::..:      :......::.|:  ..|..:.| :.||..:....|....::.||:.
plant   895 LSKPTKSALLRGH------ISGFGYGLSQCL--AFCSYALGLWYISVLIKRNETNFEDSIKSFMV 951

  Fly   702 IVMLCGIIWPIEGMFPLLQFFTAFLPLTKPTESMRSILQ 740
            :::....:.....:.|         .:.|.|:::.|:.:
plant   952 LLVTAYSVAETLALTP---------DIVKGTQALGSVFR 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	60/251 (24%)
		CcmA	54..321	CDD:224054	69/302 (23%)
		ABC2_membrane_3	394..770	CDD:289468	64/378 (17%)
		ABC2_membrane	<581..738	CDD:279410	27/170 (16%)
ABCB14	NP_174122.1	PTZ00265	47..1243	CDD:240339	148/754 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910