DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and ABCB1

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_181228.1	Gene:	ABCB1 / 818265	AraportID:	AT2G36910	Length:	1286	Species:	Arabidopsis thaliana

Alignment Length:	556	Identity:	123/556 - (22%)
Similarity:	217/556 - (39%)	Gaps:	120/556 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AAADGVPPTAPAATATTANSDLDLAARRRLFISQPSTLATRRQQAV-------CVRRAHKMYGSS 60
            |.....|..|..|.|..|      ||:....|....|:....:..|       .|...:..:...
plant   320 ALGQSAPSMAAFAKAKVA------AAKIFRIIDHKPTIERNSESGVELDSVTGLVELKNVDFSYP 378

  Fly    61 KNPNV-VLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEI-------------WVL 111
            ..|:| :|:...::||.|....|:|:||.||:|::|.|......|||::             |:
plant   379 SRPDVKILNNFCLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPNSGQVLLDGQDLKTLKLRWL- 442

  Fly   112 GGRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLPNA 176
                        ..:||.:.||.||:.. :::|.::       :.:.| .|:.| :.:...:.||
plant   443 ------------RQQIGLVSQEPALFAT-SIKENIL-------LGRPD-ADQVE-IEEAARVANA 485

  Fly   177 SKFV---------------KNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLV 226
            ..|:               ..|||||::|:::|.|:|..|.:|:|||.|..:|....:.:.:.|
plant   486 HSFIIKLPDGFDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEAL- 549

  Fly   227 DITKNGHTTVIITTHYIDECAQAHMIGLLRGGKMLAEESPDYLRQQYNADSLEDVFLKLSVLQN- 290
            |....|.||:|| .|.:....:|.::.:|:.|.:....:.|.|..:    ....|:.||..:|.
plant   550 DRFMIGRTTLII-AHRLSTIRKADLVAVLQQGSVSEIGTHDELFSK----GENGVYAKLIKMQEA 609

  Fly   291 -----MGKRRRSSIAQEIVEQVTVPAISNPALDMSDEQHAAEISGEFGDNISMSSAARDPISTTA 350
                 |...|:||........    ::|:|.:..:.....:..|....|    .|.:...:|..|
plant   610 AHETAMSNARKSSARPSSARN----SVSSPIMTRNSSYGRSPYSRRLSD----FSTSDFSLSIDA 666

  Fly   351 PAAPPLPPP----QEIPTSFWYNLHVMQSHHLHALIWKNFLWMMRNVG-VMLFIVGLPVVQILLF 410
            .:.|.....    ::...||| .|..|.|..     ||..|  :.:|| |:...:......:|..
plant   667 SSYPNYRNEKLAFKDQANSFW-RLAKMNSPE-----WKYAL--LGSVGSVICGSLSAFFAYVLSA 723

  Fly   411 CYAIGHDPTGLKLAVANHEMSGEMIMEQFCPVHTGCNQTMLSCRYL-----DMLVKN-----KSM 465
            ..::.::|        :||...:.| :::|.:..|.:...|....|     |::.:|     :..
plant   724 VLSVYYNP--------DHEYMIKQI-DKYCYLLIGLSSAALVFNTLQHSFWDIVGENLTKRVREK 779

  Fly   466 VVQYVTDDEMAY---EEVRKGRAWAALVIQPNYTAS 498
            ::..|..:|||:   ||....|..|.|.:..|...|
plant   780 MLSAVLKNEMAWFDQEENESARIAARLALDANNVRS 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	62/257 (24%)
		CcmA	54..321	CDD:224054	71/301 (24%)
		ABC2_membrane_3	394..770	CDD:289468	24/119 (20%)
		ABC2_membrane	<581..738	CDD:279410
ABCB1	NP_181228.1	PTZ00265	43..1264	CDD:240339	123/556 (22%)
		ABC_membrane	49..319	CDD:279056
		ABC_MTABC3_MDL1_MDL2	368..607	CDD:213216	65/267 (24%)
		ABC_membrane	705..970	CDD:279056	25/120 (21%)
		ABC_MTABC3_MDL1_MDL2	1024..1263	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910