DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and Abca6

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_671751.2	Gene:	Abca6 / 76184	MGIID:	1923434	Length:	1624	Species:	Mus musculus

Alignment Length:	779	Identity:	162/779 - (20%)
Similarity:	286/779 - (36%)	Gaps:	177/779 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QQAVCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIW 109
            ::|:.:|...|.|.........|.||.:.:.:..|..:||.||.||::||:.:.|.....:|.:.
Mouse   475 KEAIRIRNIKKEYKGKSGKVKALKGLFLDIYESQITAILGHSGAGKSSLLNILSGLYVPTAGSVT 539

  Fly   110 VLGGRPGSRGSGVPGPR--IGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLN 172
            |. .:..|....:...|  ||..||....:...|::|.|..|..|..:...|:|...:.:|..|:
Mouse   540 VY-NKNLSDMQDLKEIRKAIGVCPQHNVQFDALTVKENLTLFAKIKGILPQDVEQEVQQILSELD 603

  Fly   173 LPN-ASKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTV 236
            :.| .....::||.||:|:::..:|.:.:|::|:|||||||:||..||.||..|.:  :.....:
Mouse   604 MQNIRDDLAEHLSEGQKRKLTFGIATVGDPQILLLDEPTVGLDPFSRQRIWGFLKE--RRADHVI 666

  Fly   237 IITTHYIDECAQAHMIG----LLRGGKMLAEESPDYLRQQYNADSLEDVFLKLSVLQNMGKRRRS 297
            :.:|.::||   |.::.    |:..|.:....|..:|::::..    ...|.|.:.:.....|.:
Mouse   667 LFSTQFMDE---ADILADRKVLIANGALKCTGSSVFLKRKWGL----GYHLSLFMDETCDSERLT 724

  Fly   298 SIAQEIVEQVTVPAISNPAL-DMSDEQHAAEISGEFGD------------NISMSS--------- 340
            |.....:....:.|.:...| .:...:..:|....|.|            .:|||:
Mouse   725 SFINHHIPYAKLKAKTKEKLVYILPLERTSEFPEFFSDLDKYSGQGLMSYEVSMSTLNDVFLNLE 789

  Fly   341 -------------AARD--PISTTAPAAPPLPPPQE-IPTSFWYNLHVMQSHHLHALIWKN---- 385
                         .|.|  .::....|.|.|...|| :.|...:.:.|.....|..|..|.
Mouse   790 GEPSTKQDFEKRETATDSESLNDMEVAYPSLSQVQETVSTMSLWRMQVCAIARLRILKLKRERKA 854

  Fly   386 FLWMMRNVGVMLFIVGLPVV-----------------QILLFCYAIGHDPTGLK---LAVANHE- 429
            ||.::..:|:.|    ||:|                 :..|:..:.|..|.||:   |.:.|.|
Mouse   855 FLIILLLLGIAL----LPLVIEYVANALLEVKNNWEFKTDLYFLSPGQLPQGLRTSLLVINNTES 915

  Fly   430 -------------------------------------MSGEMIMEQFCPVHTGCNQTMLSCRYLD 457
                                                 :||.....:|..|   ||...|.|..:.
Mouse   916 NIEDFLQSLKHQNIVLEVDDFENRNATNSLSYNGAIIVSGRQKDYRFSAV---CNTKRLHCFPIL 977

  Fly   458 MLVKNKSMV-----VQYVTDDE--------MAYEEVRKGRAWAALVIQPNYTASLMERVEDGRYA 509
            |.|.:..::     .||:...|        :.:..:::...:...||........|..|.|.:..
Mouse   978 MNVISNGILHMLNHTQYIRIKEDIFSPFIVLVWTGIQETCLFILCVICSLSPHIAMSSVSDYKKK 1042

  Fly   510 EDGTIESSDLAVRMDWSNQQISQL-LYRDLQYT--FFNFVG-----DMLSD-----------CDV 555
            .|..:..|.|.....|..|.:..: |:..:..|  |.::..     ||.|:           |..
Mouse  1043 ADSQLWISGLYPSAYWCGQAVVDISLFSGMLLTSYFTSYTSKLLNIDMTSEIVFSVIVLALGCAA 1107

  Fly   556 NPKLGRVPVDFQHPVYGYRNPNFTDFAAPGVILTIIFFLAVAVTSGAMLIDRNEGMLERCLVAGI 620
            :.......:.|   |:|.|..|.|       :.:|.|.|.:|:|...:.    .|.....||  |
Mouse  1108 SLVFLTYVISF---VFGKRKKNST-------LWSICFLLVIAITFEKVA----NGPFNEALV--I 1156

  Fly   621 TGPEILLSQVVTQFTVMLSQTTFVLIVSFYF-FELTLVGNIWLVVALCILNGLCGMSFGFVISC 683
            :...::.|..:....|:|....:    .:|. ||....|...:.:.||::..:..:.|.||:.|
Mouse  1157 SATMLVPSFALNGLLVVLEMRAY----QYYIEFEEIKHGLSAVDLLLCLIPYIHTLLFIFVLRC 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	63/228 (28%)
		CcmA	54..321	CDD:224054	69/274 (25%)
		ABC2_membrane_3	394..770	CDD:289468	71/381 (19%)
		ABC2_membrane	<581..738	CDD:279410	22/104 (21%)
Abca6	NP_671751.2	rim_protein	<169..1600	CDD:130324	162/779 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900