DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and Abca12

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_780419.2	Gene:	Abca12 / 74591	MGIID:	2676312	Length:	2595	Species:	Mus musculus

Alignment Length:	973	Identity:	207/973 - (21%)
Similarity:	361/973 - (37%)	Gaps:	295/973 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TAPAATATTAN----SDLDLAARRRLFISQPSTLATRRQQAVCVRRAHKMYGSSKNPNVVLDGLN 71
            |.|:|:.|:.:    |:::         .:|..|    |..|.:....|:|||    ...::.||
Mouse  1318 TNPSASKTSPDCAFPSNIE---------PEPKDL----QVGVALHGVTKIYGS----KTAVENLN 1365

  Fly    72 MTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRIGYMPQEIAL 136
            :...:|.|..|||.:|.||||.:|.:.|.....:|.|:|. |:............:|...|...|
Mouse  1366 LNFYEGHITSLLGPNGAGKTTTISMLTGLFGATAGTIFVY-GKDIKTDLNTVRKNMGVCMQHDVL 1429

  Fly   137 YGEFTMRETLIYFGIISA--MSKGDIEDRTEFLLKLLNL-PNASKFVKNLSGGQQRRVSLAVALL 198
            :...|.:|.|:.:|.|..  .:|..:.:..:..||...| .:..|.|..||||.:|::|:::||:
Mouse  1430 FSYLTTKEHLLLYGSIKVPHWTKTQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALI 1494

  Fly   199 HEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHT-TVIITTHYIDEC-AQAHMIGLLRGGKML 261
            ....::|||||:.||||..|:||||   .|:||... |:|::||::||. ..:..|..|..|.:.
Mouse  1495 GGSRVVILDEPSTGVDPCSRRSIWD---VISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLR 1556

  Fly   262 AEESPDYLRQQY--------------NADS----------------LEDVFLK------------ 284
            ...||.||::.:              |.|:                |.:.:||
Mouse  1557 CCGSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLP 1621

  Fly   285 ----------LSVL----QNMGKRRRS--SIAQEIVEQVTV------PAISNPALDMSDEQHAAE 327
                      ||:|    :.|||....  .|:...||:|.:      ...||.:|:...::....
Mouse  1622 PFSTKVSGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKSSNMSLEHLTQRKVGN 1686

  Fly   328 ISG---EFGDNISMSSA----ARDPISTTAPAAPPLPPPQEIPTSFWYNLHVMQSHHLHALIWKN 385
            .|.   ...|::|:||:    ..|.:.|.:          |....|...|     ..:.|::.|.
Mouse  1687 PSANGTSTPDDLSVSSSNFTDRDDKVLTRS----------EKLEGFGLLL-----KKIMAILIKR 1736

  Fly   386 FLWMMRNVGVMLFIVGLPVV-------------------QILL----------FCYAIGHDP--T 419
            |....||...::..|.||:|                   :|::          ..:....||  :
Mouse  1737 FHHTRRNWKGLIAQVILPIVFVATAMGLGTLRDSSNSYPEIMISPSIYGTSEQTAFYANFDPSTS 1801

  Fly   420 GLKLAVANHEMSGEMIMEQFCPVHTGC-NQTMLSCRYLDMLVK-NKS------MVVQYVTDD--- 473
            ||..|:.|           |..:...| |.:.|.|...|.|.| |.|      ..|...:|:
Mouse  1802 GLVSALWN-----------FPGIDNVCLNTSDLQCLKKDDLGKWNTSGEAIDNFGVCSCSDNVQE 1855

  Fly   474 --EMAYEEVRKGRAWAALVIQPNYTASLMERVEDGRYAEDGTIESSDLAVRMDWSNQQISQLLYR 536
              :..|....: |.:::.||. |.|         |::.|:..|.:::..|:..:........|..
Mouse  1856 CPKFNYHPPHR-RTYSSQVIY-NLT---------GKHMENYLITTANHFVQKRYGGWSFGMKLTN 1909

  Fly   537 DLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQ--HPVYGYRNP--------NFTDFAA-------- 583
            ||::       |:.:..| |..|.:|..|.:  |.:..|.|.        |.:::.|
Mouse  1910 DLRF-------DVTAVPD-NRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSEYDAARHGIIMY 1966

  Fly   584 ----PG----------------VILTIIFFLAVAVTSGAMLIDRNEGMLERCL--VAGITGPEIL 626
                ||                |.|:|:...:|...|....|.|......:.|  ::||.
Mouse  1967 SHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYIVREHQTKAKQLQHISGIG----- 2026

  Fly   627 LSQVVTQFTVMLSQTTFVLIVSFYF----FELTLV-----------GNIWLVVALCILNGLCGMS 676
                ||.:.|    |.|:..:.||.    |.:.::           .|:..|..|.:|.|....|
Mouse  2027 ----VTCYWV----TNFIYDMVFYLVPVAFSIGVIAIFKLPAFYSGNNLGAVSLLLLLFGYATFS 2083

  Fly   677 FGFVISCAVDTERTA--TYVAMGSFLPI--VMLCGIIWPIEG--------------------MFP 717
            :.::::........|  |||.:..|..|  ::...:::.:..                    :||
Mouse  2084 WMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFP 2148

  Fly   718 LLQFFTAFLPLTKPTESMRSILQ--RGWGIDNP-------VVYNGFISISSWVLVFLVLTILL 771
            ...|....:.|::    .:::|.  :.:|::.|       .:...|:::.|...:|.:|.:|:
Mouse  2149 QFCFGYGLIELSQ----QQAVLDFLKAYGVEYPSETFEMDKLGAMFVALVSQGTMFFLLRLLI 2207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	74/226 (33%)
		CcmA	54..321	CDD:224054	92/335 (27%)
		ABC2_membrane_3	394..770	CDD:289468	90/507 (18%)
		ABC2_membrane	<581..738	CDD:279410	37/225 (16%)
Abca12	NP_780419.2	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046	75/231 (32%)
		ABC_subfamily_A	1350..1565	CDD:213230	73/222 (33%)
		ABC2_membrane_3	<1913..2174	CDD:289468	48/285 (17%)
		CcmA	2253..2567	CDD:224054
		ABC_subfamily_A	2254..2477	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810