DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and abcg2d

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_009292498.3	Gene:	abcg2d / 735310	ZFINID:	ZDB-GENE-050517-38	Length:	658	Species:	Danio rerio

Alignment Length:	803	Identity:	158/803 - (19%)
Similarity:	278/803 - (34%)	Gaps:	281/803 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLN--SGEIWV 110
            ||.|       ::....::|| ||..:..| :..:||.:|.||::.|..:.||:...  |||:.|
Zfish    56 VCRR-------TTVQKEILLD-LNGIMRPG-LNAILGPTGSGKSSFLDVLAGRKDPAGLSGEVLV 111

  Fly   111 LGGRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGII---SAMSKGDIEDRTEFLLKLLN 172
            .|....:....:.    ||:.|:..:.|..|:||.|.:...:   |.:|..:.|.|...|:..|.
Zfish   112 NGALQPANFKCLS----GYVVQDDIVMGTLTVRENLSFSAALRLSSHVSPREKEARVNHLISELG 172

  Fly   173 LPN------ASKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKN 231
            |..      .::.::.:|||:::|.|:.:.|:.:|.:|.|||||.|:|.....|:...|..:...
Zfish   173 LNKVADSKVGTQIIRGISGGERKRTSIGMELIIDPSVLFLDEPTTGLDASTAHSVLLLLKRMAGQ 237

  Fly   232 GHTTVIITTH--------YIDECAQAHMIGLLRGGKML----AEESPDYLR------QQYN--AD 276
            |. |:|::.|        ..|.      :.||..||.:    |:::.||..      :.:|  ||
Zfish   238 GR-TIIMSIHQPRFSIYRLFDS------LTLLANGKQVYHGPAQDALDYFSNIGYACEAHNNPAD 295

  Fly   277 SLEDVFLKLSV--LQNMGKRR-------RSSIAQEIVEQVTVPAISNPALDMSDEQHAAEISGEF 332
            ...||....||  :||.|...       |.|:..:::|:....:.:...        .||:
Zfish   296 FFLDVINGSSVTKIQNNGDAECDVSAVSRQSVEDQLMEKYRSCSFARAV--------RAEL---- 348

  Fly   333 GDNI------SMSSAARDPISTTAPAAPPLPPPQEIPTSFWYNLHVMQSHHLHALIWKNFLWMMR 391
             |:|      |.||.|.:..|.|            ..:||        ...|..::|:.|..:|.
Zfish   349 -DHIIQTKDSSSSSVAAECHSIT------------YSSSF--------CQQLRWVLWRTFWNLML 392

  Fly   392 N----------VGVMLFIVGLPVVQILLFCYAIGHDPTGLKLAVANHEMSGEMIMEQFCPVHTGC 446
            |          ..:|..|||      .:| |.:..|.:|::      ...|.:    |......|
Zfish   393 NPQTSVAQLAVTTLMAAIVG------AIF-YGVKDDQSGIQ------NRFGVL----FFITTNQC 440

  Fly   447 NQTMLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAWAALVIQPNYTASLMERVEDGRYAED 511
            ..|:             |....::|:.::...|...|          .|..|:.
Zfish   441 FSTL-------------SAAELFITERKLFIHEYTSG----------YYRVSVF----------- 471

  Fly   512 GTIESSDLAVRMDWSNQQISQLLYRDLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQHPVYGYRNP 576
                                             |:..:|||.
Zfish   472 ---------------------------------FLSKILSDI----------------------- 480

  Fly   577 NFTDFAAPGVILT--IIFFLAVAVTSGAMLIDRNEGMLERCLVAGITGPEILLSQVVTQFTVMLS 639
             .|....|.|:.:  :.|.:.:..|:.|..|.....:|..|..|.       ::..::....:::
Zfish   481 -ITQRTIPSVLFSCVVYFMIGLKPTASAFFIFMLTVILVSCTAAA-------MAMAISADQSVVA 537

  Fly   640 QTTFVLIVSFYFFEL--TLVGNI-----WL--VVALCI---------LNGLCGMSFGFVISCAVD 686
            ....::.|||.|..:  .|:.|:     ||  :..|.|         :|...|:||     |...
Zfish   538 VANILMTVSFIFMMIFSGLLVNLKSIMDWLSWLKYLSIPRYGLEALEINEFVGLSF-----CGNV 597

  Fly   687 TERTATYVAMGSFLPIVMLCGIIWPIEGMFPLLQFFTAFLPLTKPTESMRSILQRGWGIDNPVVY 751
            :|..|:..|.      |::|                |....||     .:.|....||:     :
Zfish   598 SESLASPAAH------VLMC----------------TGEQHLT-----FQGIDYSSWGL-----W 630

  Fly   752 NGFISISSWVLVFLVLTILLLKF 774
            ...::::...|:||::..:.|:|
Zfish   631 QNHVALTVMTLIFLIIAYIKLRF 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	65/244 (27%)
		CcmA	54..321	CDD:224054	75/306 (25%)
		ABC2_membrane_3	394..770	CDD:289468	61/395 (15%)
		ABC2_membrane	<581..738	CDD:279410	32/176 (18%)
abcg2d	XP_009292498.3	PRK10535	56..658	CDD:333000	158/803 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000