DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and Abca14

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_017167760.1	Gene:	Abca14 / 67928	MGIID:	2388708	Length:	1719	Species:	Mus musculus

Alignment Length:	846	Identity:	173/846 - (20%)
Similarity:	331/846 - (39%)	Gaps:	194/846 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGR 114
            ::..:|.:....:..:.::.|::.:.:|.|..|||.:|.||||.||.:.|......|::::.|..
Mouse   558 IQHLYKEFILKNSTLMAVNDLSLNLYEGQITVLLGHNGAGKTTTLSILTGLYLPTRGKVYISGYD 622

  Fly   115 PGS-----RGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLP 174
            ..|     |.|      :|..||:..|:...|:.|.|.::.:|..:...:....|..:|....|.
Mouse   623 ISSDMVQIRKS------LGLCPQDDLLFPMLTVSEHLHFYCVIKGIPLQNQSRETNRMLTSFGLL 681

  Fly   175 NASKFV-KNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVII 238
            ..|..: |:||||.:|::|:.:||:.:.:::||||||.|:|||.|::.||.|....|:  .|:::
Mouse   682 QQSNTMSKDLSGGMKRKLSIIIALIGDTKVVILDEPTSGMDPVSRRATWDLLQHYKKD--RTILL 744

  Fly   239 TTHYIDEC-AQAHMIGLLRGGKMLAEESPDYLRQQYNA----------DSLEDVFLKLSVLQNMG 292
            |||::||. .....|.:|..|.:....|..:|::.|..          ||.::...:|.......
Mouse   745 TTHHMDEADVLGDRIAILVMGILKCCGSSLFLKKLYGVGYHLVIVKTPDSNDEKIFQLIKNYIPT 809

  Fly   293 KRRRSSIAQE---IVEQVTVPAISNPALDMSDEQHAAEISGEFG------DNISMSSAARDPIST 348
            .:..:::|.|   |:.:......:....|:.::|....||| ||      |.:....:..:.:..
Mouse   810 AKMETNVAAELSFILPKEHTHRFAELFTDLEEKQEELGISG-FGVSMTTMDEVFFKVSNLEDLKL 873

  Fly   349 TAPAAPP----------------LPPPQEIP--------TSF---WYNLHVMQSHHLHALIWKNF 386
            ....||.                :|...|.|        :||   | :|::.|   ..|:..|..
Mouse   874 NTEIAPSASIVSQSSNEDNQNMNVPRNFERPGYSRRHLDSSFNAGW-SLYIQQ---FRAMFIKRV 934

  Fly   387 LWMMRNVGVMLF----IVGLPVVQILLFCYAIGHDPTGLKLAVANHEMSGEMIMEQFCPVHTGCN 447
            ::..|...::|.    ::||..:.|....:::..:|.    .|.:.|..||.|:.  ..|....|
Mouse   935 MFSWRYWKLLLLQLLALLGLMYLLIKGISFSVPKEPA----RVMDLEQYGETIVP--FSVSGDPN 993

  Fly   448 QTMLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAWAALVIQPNYTASLMERVEDGRYAEDG 512
            .|.:..:.|:.::|.|...:..|..|...|....|...::.:|                .::.|.
Mouse   994 LTQILTKNLETMLKAKKQKIHEVQGDMKNYLLTSKDCIYSCIV----------------AFSLDV 1042

  Fly   513 TIESSDLAVRMDWSNQQ-----------ISQLLYR-----DLQYTFFNFVGDMLSDCDVNPKLGR 561
            |.|....   :.|.|.:           :..::|:     |...|..|           ||:..|
Mouse  1043 TTEEKTF---IFWFNNEAYHAAPLSLSILDNIIYKYLSGPDATITVSN-----------NPQPQR 1093

  Fly   562 VPVDFQHPVYGYRNPNFTDFAAPGVILTIIFFLAVAVTSGAMLIDRNEGMLER---CLVAGI--- 620
            |..|         ..|....:...::..::|.::: .|||..|:...|.:.:.   ..|:|:
Mouse  1094 VTKD---------KSNERSISGIQIVFNLLFGMSI-FTSGFCLMTVTERVSKAKHIQFVSGVYTL 1148

  Fly   621 ---------------------------TGPEILLSQ---VVTQFTVML---SQTTFVLIVSFYFF 652
                                       |..:|||.:   :.|.|.:||   |...|:.::||::.
Mouse  1149 NFWLSALLWDLIIHFVACVLLLVVFLYTDVDILLEKYHFLDTMFILMLFGWSIIPFIYLLSFWYN 1213

  Fly   653 ELTLVGNIWLVVAL---CILNGLCGMSFGFVISCAVDTERTATYVAMGS--FLPIVMLCGIIWPI 712
            ..|   |.::.:.:   |:  |...:....|:....|.:.:...:.:.|  .|||......|:..
Mouse  1214 NST---NAYIKIFVFNHCL--GFISIIVDAVVQIIPDIKTSTKNLILNSMLLLPIYNFGMSIYKY 1273

  Fly   713 EGMFPLLQFFTAFLPLTKPTESMRSILQRGWGIDNPV-------VYNGFISISSWVLVFLVLTIL 770
            ..:..:.:..:: |.......|.:|.:     ||.|:       :.....::::..|::.:|.||
Mouse  1274 YNIHEIRKLCSS-LGYINTIPSCKSQI-----IDIPIYSMNQKAIGRHVTAMAATGLIYFILIIL 1332

  Fly   771 L 771
            |
Mouse  1333 L 1333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	66/226 (29%)
		CcmA	54..321	CDD:224054	75/286 (26%)
		ABC2_membrane_3	394..770	CDD:289468	75/446 (17%)
		ABC2_membrane	<581..738	CDD:279410	33/200 (17%)
Abca14	XP_017167760.1	rim_protein	<128..1709	CDD:130324	173/846 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810