DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and abca12

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_686632.6	Gene:	abca12 / 558335	ZFINID:	ZDB-GENE-030131-9790	Length:	5913	Species:	Danio rerio

Alignment Length:	970	Identity:	186/970 - (19%)
Similarity:	311/970 - (32%)	Gaps:	365/970 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 MYGSSK---NPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGS 117
            :||.:|   ..|.| |.||::..:|.:..|||.:|.||||.:|.:.|......|.|.|.|.....
Zfish  4668 LYGLTKTYGKRNAV-DNLNLSFYEGHVTSLLGHNGAGKTTTMSLLTGLFAPTVGTIEVYGMDMQM 4731

  Fly   118 RGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISA--MSKGDIEDRTEFLLKLLNL-PNASKF 179
            ....| ...:|...|...|:...|.:|.|:.:..|.|  .:|.:::::...:|...:: .:..|.
Zfish  4732 FIDDV-RKEMGVCMQYDVLFDHLTTKEHLLLYAQIKAPHWTKQEVKEQVHKILMETDMHAHRHKR 4795

  Fly   180 VKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYID 244
            |..||||.:|::|:::|.:....|::|||||.||||..|:||||  :.|......|:|::||::|
Zfish  4796 VGTLSGGMKRKLSISIAFIGGSRLVVLDEPTTGVDPCSRRSIWD--IIIQHKQERTIILSTHHLD 4858

  Fly   245 EC-AQAHMIGLLRGGKMLAEESPDYLRQQ----YN---------ADS------------------ 277
            |. ..:..|..|..|.:....||.||:.:    ||         |||
Zfish  4859 EAEVLSDRIAFLERGGLKCCGSPFYLKDKLAKGYNLTLTKKVETADSKEKFDYEKLRDFIHSHLP 4923

  Fly   278 ----------------------------------------------------LEDVFLKL----- 285
                                                                ||:|||:|
Zfish  4924 DARQKDREMGDLVYALPPYTPQNASEYHSLLNSLDQNLDKLHLGCYGISDTTLEEVFLQLTRDDL 4988

  Fly   286 ------------SVLQNMGKRRRSSIAQE------------------------------------ 302
                        ||::|.....|.|::::
Zfish  4989 EPKESETWSVSESVIENDMFASRDSLSEDCNSMYLGEKASLTGNSTVRGFALGVQRVIAMLLKRV 5053

  Fly   303 ---------IVEQVTVPA----------------------ISNPALDMSDEQHAAEISGEFGDN- 335
                     :..||.:|.                      :.:|||...|||:|      |..|
Zfish  5054 HHSRRDWKGLFSQVLLPVLFVIAAMGLGSIKSDLQHFPEIVLSPALYHVDEQYA------FFSNQ 5112

  Fly   336 ---------ISMSSAARDPISTTAPAAPPLPPPQEIPTSFWYN-------------LHVMQSHHL 378
                     ..||....|.:..|.|..|.........:..|.:             .:.:||
Zfish  5113 NPNTSRLVDTMMSYPGIDHVCMTDPTDPVCKGRPSTGSQTWVSGGNSSATFTTCKCSNQVQS--- 5174

  Fly   379 HALIWKNFLWMMRNVGVMLFIVGLPVVQILLFCYAIGHDPTGLKLAVANHEMSGEMIMEQFCPVH 443
                                            |.|.|:||.                 .:.||
Zfish  5175 --------------------------------CPAQGYDPP-----------------RKRCP-- 5188

  Fly   444 TGCNQTMLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAWAALVIQPNYTASLMERVEDGRY 508
                               .|.:|..:|.                 |...||..:........||
Zfish  5189 -------------------SSQIVYNLTG-----------------VNIENYLLATANNFIRDRY 5217

  Fly   509 A--EDGTIESSDLAVRMDW----SNQQISQLLYRDLQY----TFFNFVGDMLSDCDVNP-KLGRV 562
            .  |.|.....||  :||.    :|:.:|::.|....:    .:.|.:.:......:.| |..:.
Zfish  5218 GGWEFGKPLPIDL--KMDMLDVPANRTLSKVWYNSEGHHSMPAYLNSLNNFFLRSSLPPEKRYQY 5280

  Fly   563 PVDF-QHPVYGYRNPNFTDFAAPGVILTIIFFLAVAVTSGAMLI----------DRNEGMLERCL 616
            .:.. .||..|.....  |....|::..::   |:.|.:|..::          :.:.|......
Zfish  5281 AISISSHPYPGQVQDE--DLMVGGLVSILV---ALCVLTGYSIMTASFVIYEVQEHHTGSKRLQQ 5340

  Fly   617 VAGITGP-----EILLSQVVTQFTVMLSQTTFVLIVSFYFFELTLVGNIWLVVALCILNGLCGMS 676
            ::||:.|     .......:....|:||   .|::.:|.....|...|:..|..|.:|.|.....
Zfish  5341 ISGISEPFYWIINFFYDMALYMIPVVLS---VVMVAAFQLPAFTERQNLAAVTLLLVLFGFSTFP 5402

  Fly   677 FGFVISCAV-DTERT-ATYVAMGSFLPI--VMLCGIIW----------PIEG----------MFP 717
            :.:::|... |||.. ..||.:..|:.:  ::...||:          .|:.          :||
Zfish  5403 WMYLLSAMFKDTEMAFIGYVCINLFISVNTIISTSIIYFLGQLNQNDQSIQNIYQTMSNIFLVFP 5467

  Fly   718 LLQFFTAFLPLTKPTESMRSILQRGWGID---NPVVYN--GFISISSWVLVFLVLTILLL 772
            ...|....:.|.:  ..|:..:..|:|:|   ||...:  |::.||.::..|:..|:.||
Zfish  5468 QFSFGNGLMELAR--VDMQVQILSGFGVDAYKNPFSMDVLGWMFISMFLQGFICFTLRLL 5525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	71/220 (32%)
		CcmA	54..321	CDD:224054	94/438 (21%)
		ABC2_membrane_3	394..770	CDD:289468	75/431 (17%)
		ABC2_membrane	<581..738	CDD:279410	34/195 (17%)
abca12	XP_686632.6	ABC2_membrane_3	4268..4588	CDD:289468
		CcmA	4666..4941	CDD:224054	77/276 (28%)
		ABC_subfamily_A	4666..4885	CDD:213230	71/220 (32%)
		ABC2_membrane_3	<5245..5493	CDD:289468	43/257 (17%)
		CcmA	5572..5886	CDD:224054
		ABC_subfamily_A	5573..5799	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910