DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33970 and snu

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster

Alignment Length:	789	Identity:	401/789 - (50%)
Similarity:	520/789 - (65%)	Gaps:	37/789 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PAATATTANSDLDLAARRRLFISQPSTLAT---------RRQQAVCVRRAHKMYGSSKNPNVVLD 68
            |:|..:|   |..:||......:||:.:|.         ..|.||.||.|.|.||..||.|.||:
  Fly    33 PSAIIST---DSAMAATNNDGGTQPNAVAAWGAPANGPRNTQAAVSVRHAFKAYGKKKNANQVLN 94

  Fly    69 GLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRIGYMPQE 133
            .||||||||:|||||||||||||||||||||||.:::|||:||||:||:|||||||.|:||||||
  Fly    95 NLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQE 159

  Fly   134 IALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLPNASKFVKNLSGGQQRRVSLAVALL 198
            |||||||:::||::|||.|..|...:|.:|.:|||..|:||:..:.|||||||||||||.||||:
  Fly   160 IALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNFLDLPSEKRLVKNLSGGQQRRVSFAVALM 224

  Fly   199 HEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDECAQAHMIGLLRGGKMLAE 263
            |:|||||||||||||||:||||||:|||.|||.|..|||||||||:|..|||.|||:|.|.:|||
  Fly   225 HDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEARQAHTIGLMRSGHLLAE 289

  Fly   264 ESPDYLRQQYNADSLEDVFLKLSVLQNMGKRRRSSIAQ-EIVEQVTVPAISNPALDMSDEQHAAE 327
            |||..|...|...|||:||||||.:|:    ::..:.. .....:::.|::..:  ..|:..:::
  Fly   290 ESPSVLLSIYKCISLEEVFLKLSRIQS----QKGDVTHVNFSNNISLHAMAFGS--KMDKPSSSQ 348

  Fly   328 ISGEFGDNISMSSAARDPIST----TAPAAPPLPPP---------QEIPTSFWYNL-HVMQSHHL 378
            ..|..|.|...|.......|.    |....|..|||         :|.....:.|| .:.....:
  Fly   349 EGGVVGLNFHQSKEVLINDSNGSIYTLNQEPYSPPPSRRNNNPNDEESCQDCYSNLCKITSKGKI 413

  Fly   379 HALIWKNFLWMMRNVGVMLFIVGLPVVQILLFCYAIGHDPTGLKLAVANHEMSGEMIMEQFCPVH 443
            .||:.||.|.|.|||||||||..|||:|::|||.|||.||.||.||:.|.||: :.:.|. |...
  Fly   414 RALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDPQGLNLAIVNGEMN-DTVREN-CYWE 476

  Fly   444 TGCNQTMLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAWAALVIQPNYTASLMERVEDGRY 508
            .||:...|.||||..|  |.|:|..|..|.:.|.|.||||.||.|:.|..|:|.:.:.|...||.
  Fly   477 DGCHFKNLGCRYLSHL--NTSVVKTYYEDLDDAKEAVRKGTAWGAVYISENFTDAFIARANLGRD 539

  Fly   509 AEDGTIESSDLAVRMDWSNQQISQLLYRDLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQHPVYGY 573
            ::|.||:||::.|.:|.|||||..:|.||:|..|.:|...:|..|..|||||.||:.|:.|:||.
  Fly   540 SDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLAFRDFAMGLLGQCGSNPKLGDVPIQFRDPIYGT 604

  Fly   574 RNPNFTDFAAPGVILTIIFFLAVAVTSGAMLIDRNEGMLERCLVAGITGPEILLSQVVTQFTVML 638
            .||:||||.||||||||:||||||:||.|::|:|.||:|:|..|||::..|||.|.|:|||.||.
  Fly   605 MNPSFTDFVAPGVILTIVFFLAVALTSSALIIERTEGLLDRSWVAGVSPFEILFSHVITQFVVMC 669

  Fly   639 SQTTFVLIVSFYFFELTLVGNIWLVVALCILNGLCGMSFGFVISCAVDTERTATYVAMGSFLPIV 703
            .|||.|||.....|.:|..|:::.|:.|.:|.|:|||.|||:||...:.||.|..:|:|||.|.:
  Fly   670 GQTTLVLIFMLVVFGVTNNGDLFWVIVLTLLQGMCGMCFGFLISSVCELERNAIQLALGSFYPTL 734

  Fly   704 MLCGIIWPIEGMFPLLQFFTAFLPLTKPTESMRSILQRGWGIDNPVVYNGFISISSWVLVFLVLT 768
            :|.|:|||||||..:|::.:..||||..|.|:||||.|||.|....||.|::|..||::.|||||
  Fly   735 LLSGVIWPIEGMPVVLRYISLCLPLTLATSSLRSILTRGWAILESDVYIGYVSTLSWIVGFLVLT 799

  Fly   769 ILLLKFKKG 777
            :|:|:.|:|
  Fly   800 LLVLRAKRG 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	158/221 (71%)
		CcmA	54..321	CDD:224054	167/267 (63%)
		ABC2_membrane_3	394..770	CDD:289468	192/375 (51%)
		ABC2_membrane	<581..738	CDD:279410	83/156 (53%)
snu	NP_651628.1	LolD	73..290	CDD:224059	155/216 (72%)
		ABC_DR_subfamily_A	74..286	CDD:213197	152/211 (72%)
		pip_yhgE_Nterm	427..>474	CDD:276270	28/48 (58%)
		ABC2_membrane_3	429..801	CDD:289468	192/375 (51%)
		ABC2_membrane	601..769	CDD:279410	90/167 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469451
Domainoid	1	1.000	183	1.000	Domainoid score	I3362
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	560	1.000	Inparanoid score	I1061
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125121at33208
OrthoFinder	1	1.000	-	-		FOG0000498
OrthoInspector	1	1.000	-	-		mtm6564
orthoMCL	1	0.900	-	-		OOG6_103922
Panther	1	1.100	-	-	P	PTHR43038
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2776
	11	10.800