DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33970 and CG42816

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	163/764 - (21%)
Similarity:	296/764 - (38%)	Gaps:	199/764 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLG 112
            |.:|...|.:|..:    |:..::..:.:|.|..|:|.:|.|||||:|.:.|.....||...:.|
  Fly   339 VQIRGLSKTFGKME----VVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALING 399

  Fly   113 ------GRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLL 171
                  .|...|       .||..||:..|:...:....:..|..:..:...:::...:..||.|
  Fly   400 FDIRQERRQAQR-------CIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKL 457

  Fly   172 NLPNASKF-VKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTT 235
            ||....:. .:|||||.|||:|:|.:|....::||.|||:.|:||..|:.:| .|:...|.| .|
  Fly   458 NLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELW-RLILEAKEG-CT 520

  Fly   236 VIITTHYIDECAQAHMIG----LLRGGKMLAEESPDYLRQQYNADSL------------------ 278
            :::|||.:|:   ..::|    ::..|::....|..:|::|.:|..|
  Fly   521 ILLTTHQLDD---GEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCLITCEARKRCDLEKLTSLI 582

  Fly   279 --------------EDVFLKLSVLQNMGKRRRSSIAQEIVEQVTVPAISNPALDMSDEQHAAEIS 329
                          .||..||.:.::   :..||:.:::..|:.:..:...:|        :.:|
  Fly   583 SRHVGTIQPFSIKGRDVCYKLPLSKS---KYFSSLFRDLESQMNILGVRGFSL--------SSVS 636

  Fly   330 GEFGDNISMSSAARDPISTTAPAAPPL-------PPPQEIPTSFWYNLHVMQSHHLHALIWKNFL 387
            .|   .|.||..|.|..|..:..|...       ....|:...   |:...:. ...|::.|..:
  Fly   637 LE---EIFMSFGAEDLNSRQSGGAEKRDDDDRDDDEENEVQDG---NVRSCKK-QWRAMMTKKVM 694

  Fly   388 WMMRNVGVMLFIVGLPVVQILLFCYAIGHDPTGLKLAVANHEMSGEMIMEQFCPVHTGCNQTMLS 452
            .:..|....|.::..|:|..:          |.|.:|...|              |:|.....:|
  Fly   695 ALYDNKVYFLLLLLTPIVYYI----------TTLMMATKPH--------------HSGRPTFNIS 735

  Fly   453 CRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAWAALVIQPNYTASLMERVEDGRYAEDGTIESS 517
            ...:|......|:.|      ..:|.|.|:..:.|:|:........:.|:::|  |.:|
  Fly   736 DYGVDKFTILLSVPV------SKSYTEERRADSIASLIKGKLKLIVVSEQIKD--YVDD------ 786

  Fly   518 DLAVRMDWSNQQISQLLYRDLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQHPVYGYRNPNFTDFA 582
                  .|.:::..:.:         |||...:   |...:.|.:         |:..|.....|
  Fly   787 ------KWKSREGRREI---------NFVSMAI---DTGDRTGLI---------GWVGPRHYVHA 824

  Fly   583 APGVILTIIF----------FLAVAVTSGAMLIDR-------NEGMLERCLVAGITGPEILLSQV 630
            || :||.:::          .:::.|||....:.:       |.|.:...::..::...|:.|..
  Fly   825 AP-MILNLVYNALAQELIGPKISIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMIIFSSA 888

  Fly   631 VTQ-----------------FTVMLSQTTFVLIVSFYFFELTLVGNI-----WLVVALCIL--NG 671
            |.|                 .|..||...|.::| |:...|.|:..:     |.:: ||:|  .|
  Fly   889 VIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVV-FFILVLALLLPLYGYAPWYLL-LCVLFFTG 951

  Fly   672 LCGMSF-GFVISCAVDTERTATYVAMGSFLPIVMLCGIIWPIEGMFPLL 719
            |.|:.| .|:||..     :||::|:...|..|::..:|..|.|...|:
  Fly   952 LAGLIFIYFLISML-----SATFLAVSMILLSVIIGSLILMILGALALI 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	65/232 (28%)
		CcmA	54..321	CDD:224054	75/309 (24%)
		ABC2_membrane_3	394..770	CDD:289468	72/368 (20%)
		ABC2_membrane	<581..738	CDD:279410	42/181 (23%)
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	80/333 (24%)
		ABC_subfamily_A	339..556	CDD:213230	65/232 (28%)
		ABC2_membrane_3	<821..1018	CDD:289468	42/183 (23%)
		CcmA	1135..1450	CDD:224054
		ABC_subfamily_A	1136..1354	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46598
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810