DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33970 and CG11147

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_608954.1	Gene:	CG11147 / 33803	FlyBaseID:	FBgn0031734	Length:	711	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	283/744 - (38%)
Similarity:	439/744 - (59%)	Gaps:	51/744 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 AVCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVL 111
            ||.||..:|.|||..||.:||:.|||.|.:|||||||||||||||||||||||:||||.||:.||
  Fly     3 AVEVRNGYKYYGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVL 67

  Fly   112 GGRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLPNA 176
            |.:||..||||||.|:|:|||||||..|.|::||:.|||.|..::...|.::.:.|.:||.||.|
  Fly    68 GAKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLTDERIREKFKLLKELLQLPPA 132

  Fly   177 SKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTH 241
            .:.:|..|||||||:|.|.|::|:||||||||||||:||:||:.|||.||:.|:|....||||||
  Fly   133 RQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIITTH 197

  Fly   242 YIDECAQAHMIGLLRGGKMLAEESPDYLRQQYNADSLEDVFLKLSVLQNMGKRRRSSIAQEIVEQ 306
            ||:|..||:.|||:|.|.:|||::|..:..::...|:||.||.||  |..|
  Fly   198 YIEEAKQANCIGLMRNGVLLAEDTPTNIMIKFGTQSIEDAFLILS--QRQG-------------- 246

  Fly   307 VTVPAISNPALDMSDEQHAAEISGEFGDNISMSSAARDP--ISTTAPAAP---PLP---PPQEIP 363
                          :|...|:|. :...|.::.:|...|  |.|..|..|   |:|   |..|..
  Fly   247 --------------NEDELAQIM-DHNKNQALPAAVLPPEVIDTHEPNMPEKQPIPFEEPLNENR 296

  Fly   364 TSFWYNLHVMQSHHLHALIWKNFLWMMRNVGVMLFIVGLPVVQILLFCYAIGHDPTGLKLAVANH 428
            ...::.    ....:.||:.|||:.:.|....::|::..|::|:..|..|||..||.|::.|.:.
  Fly   297 KKIFFT----TKGRVKALMTKNFVQLFRQPSGIIFMLLFPIIQLTCFYLAIGKTPTNLEIGVYSG 357

  Fly   429 EMS--GEMIMEQFCPVH-----TGCNQTMLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAW 486
            |:.  ||...|....|:     ..|....|||||:.:|..:.:....|.::.: |..:.::....
  Fly   358 EVENYGECFDENLVTVYKDSDNESCLFNKLSCRYIRVLGDDVATRKYYASEAD-ALNDAKRATTV 421

  Fly   487 AALVIQPNYTASLMERVEDGRYAEDGTIESSDLAVRMDWSNQQISQLLYRDLQYTFFNFVGDMLS 551
            ..|....|::.|::..:|||.::.||.::.::|::.:|.::||::..:.|.|:..|..|:..::.
  Fly   422 GYLHFAQNFSDSILSVMEDGIHSSDGAVDHAELSIHIDMTDQQVAYFMQRKLRDKFSTFMRSVVK 486

  Fly   552 DCDVNPKLGRVPVDFQHPVYGYRNPNFTDFAAPGVILTIIFFLAVAVTSGAMLIDRNEGMLERCL 616
            ||:|:..:..:||.||.|::|..:..|..:.||||::|::||||..:|:...:.:|.:|:.:|.|
  Fly   487 DCNVSTAIVDLPVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISERMDGIWDRTL 551

  Fly   617 VAGITGPEILLSQVVTQFTVMLSQTTFVLIVSFYFFELTLVGNIWLVVALCILNGLCGMSFGFVI 681
            :||::..|:|.:.::||..:|..|:..|::.....|:....|:...::.|..|...|||.||..|
  Fly   552 LAGVSATEMLWAHLLTQLIIMALQSFEVIMYIGLVFDTYNNGDTTTLIGLLTLTAFCGMLFGLFI 616

  Fly   682 SCAVDTERTATYVAMGSFLPIVMLCGIIWPIEGMFPLLQFFTAFLPLTKPTESMRSILQRGWGID 746
            |....:...|.:||.|:|.|:::|||::||:|.|...||.....||.|.|:.|.|:::::||.|.
  Fly   617 SVFCKSHTEANFVATGAFYPMIILCGLLWPLESMPQFLQDLVMVLPFTIPSISARNVIEKGWSIT 681

  Fly   747 NPVVYNGFISISSWVLVFLVLTILLLKFK 775
            :..|||||:.::.|.::|.||.::.::.|
  Fly   682 HEKVYNGFLVMAGWTIIFFVLCLIGIRRK 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	134/221 (61%)
		CcmA	54..321	CDD:224054	140/266 (53%)
		ABC2_membrane_3	394..770	CDD:289468	118/382 (31%)
		ABC2_membrane	<581..738	CDD:279410	55/156 (35%)
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	153/309 (50%)
		P-loop_NTPase	4..222	CDD:304359	133/217 (61%)
		ABC2_membrane_3	322..702	CDD:289468	116/380 (31%)
		ABC2_membrane	469..664	CDD:279410	65/194 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464462
Domainoid	1	1.000	183	1.000	Domainoid score	I3362
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I357
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125121at33208
OrthoFinder	1	1.000	-	-		FOG0000498
OrthoInspector	1	1.000	-	-		mtm6564
orthoMCL	1	0.900	-	-		OOG6_103922
Panther	1	1.100	-	-	P	PTHR43038
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2776
	11	10.800