DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33970 and Abca6

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_006247716.1	Gene:	Abca6 / 303639	RGDID:	1308998	Length:	1630	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	73/284 - (25%)
Similarity:	132/284 - (46%)	Gaps:	29/284 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NSDLDLAARRRLFISQPSTLATRRQQAVCVRRAHKMYG-------SSKNPNVVLDGLNMTVPKGS 78
            :.|.|:.|.|.......||:....:.|:.....||.|.       |.:...:.:..::..|.||.
  Rat  1254 DEDEDVQAERMRTSDALSTVNLDEKPAIIASCLHKEYTGQKKWCCSKRRKKIAVRNISFCVNKGE 1318

  Fly    79 IYGLLGASGCGKTTLLSCIVGRRRLNSGEIWV--LGGRPGSRGSGVPGPRIGYMPQEIALYGEFT 141
            |.||||..|.||::.|..|.|..:..:||:.:  |......:|.|....::||.|||..|:...|
  Rat  1319 ILGLLGPEGAGKSSSLRMIAGIMKPTAGEVELKELSSAVAHQGEGHGAAKLGYCPQENVLWPILT 1383

  Fly   142 MRETLIYFGIISAMSKGDIEDRTEFLLKLLNLPNASKF-------VKNLSGGQQRRVSLAVALLH 199
            ::|.|..:..:..:.|.|.      ::.:..|.||.|.       .:||..|..|::..|:::|.
  Rat  1384 VKEHLEVYAAVKGLRKKDA------VIAISRLVNAFKLHDQLNVQARNLVVGLTRKLCFALSILG 1442

  Fly   200 EPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDE----CAQAHMIGLLRGGKM 260
            ...:||||||:.|:|...:|.:|..:....|:....|:::||.:.|    |.:|   .::..|::
  Rat  1443 NSPVLILDEPSTGLDVSGKQQMWQAIQAAVKDNKKGVLLSTHDLAEAEALCDRA---AIMVSGRL 1504

  Fly   261 LAEESPDYLRQQYNADSLEDVFLK 284
            ....|..:|::::..|.:.::.:|
  Rat  1505 RLIGSIQHLKRRFGKDYILELRVK 1528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	63/241 (26%)
		CcmA	54..321	CDD:224054	66/251 (26%)
		ABC2_membrane_3	394..770	CDD:289468
		ABC2_membrane	<581..738	CDD:279410
Abca6	XP_006247716.1	ABC2_membrane_3	35..420	CDD:289468
		ABC2_membrane_4	220..409	CDD:289500
		CcmA	480..795	CDD:224054
		ABC_subfamily_A	482..705	CDD:213230
		ABC2_membrane_3	859..1171	CDD:289468
		ABC2_membrane_4	1007..1178	CDD:289500
		CcmA	1279..1605	CDD:224054	67/259 (26%)
		ABC_subfamily_A	1300..1514	CDD:213230	59/222 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900