DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33970 and Abca7

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_997481.1	Gene:	Abca7 / 299609	RGDID:	1303134	Length:	2170	Species:	Rattus norvegicus

Alignment Length:	997	Identity:	208/997 - (20%)
Similarity:	328/997 - (32%)	Gaps:	378/997 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLG 112
            |.:|...|.:..|..|  .|.|||:...:|.|...||.:|.||||.||.:.|....:||...:||
  Rat   805 VSIRGLKKHFRGSPQP--ALRGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILG 867

  Fly   113 GRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNL-PNA 176
            ....:..:.: .|.:|..||...|:...|:.|.:.::|.:..:|...|:...|.|::.:.| |..
  Rat   868 HDVQTNMAAI-RPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAIDSEQEHLIRDVGLIPKR 931

  Fly   177 SKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTH 241
            ....::||||.||::|:|:|.:....::|:||||.||||..|:.||:.|:...:.  .|:|::||
  Rat   932 DTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREG--RTLILSTH 994

  Fly   242 YIDECAQAHMIG----LLRGGKMLAEESPDYLRQQY----------NADSLEDVFLK-------- 284
            ::||   |.::|    ::..|.:....||.:||:..          ::.||....||
  Rat   995 HLDE---AELLGDRVAMVASGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDLKGDTEDPRR 1056

  Fly   285 -----------LSVLQNMGKRRRS----------------------------------------- 297
                       .:||...|..|.|
  Rat  1057 EKKSGSEGKTADTVLTRDGPHRSSQVPAPDAVPVTPSAALILELVQRHVPGAQLVEELPHELVLA 1121

  Fly   298 ------------SIAQEIVEQ-----VTVPAISNPALD-----MSDEQHAAEISGEFGD---NIS 337
                        ::.||:.:|     :|...||:..|:     :.:|.||   .||.||   ...
  Rat  1122 LPYAGALDGSFATVFQELDQQLERLGLTGYGISDTNLEEIFLKVVEEAHA---HGEGGDPRQQQH 1183

  Fly   338 MSSAARDPISTTAPAA-------------PPLPPPQEIPTSFWYNLHVMQSHHLHALIWKNFLWM 389
            :.:|...|  .|.|.|             .|..|....||:.......:....|.||:.|.||..
  Rat  1184 LLTATPQP--HTGPEASVLENGELAKLVLDPQAPKGSAPTTAQVQGWTLTCQQLRALLHKRFLLA 1246

  Fly   390 MRN--------------VGVMLFIVGL-------------PVV---QILLFCYAIGHDPTGLKLA 424
            .|:              ||:.||...:             |.:   |:..|......||..:||.
  Rat  1247 RRSRRGLFAQIVLPALFVGLALFFTLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPADPNRMKLL 1311

  Fly   425 VANHEMSGEMIMEQFCPVHTGCNQTMLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAWAAL 489
            .|   :.||..::.  |...|.......|.:         .:..|.|..|:
  Rat  1312 EA---LLGEAGLQD--PSVQGKGSRGSECTH---------SLACYFTVPEV-------------- 1348

  Fly   490 VIQPNYTASLMERVEDGRYAEDGTIESSDLAVRMDWSNQQISQLLYRDLQYTFFNFVGDMLSDCD 554
               |...||::   ..|.:..|....:.           |.||...|.|           |.||.
  Rat  1349 ---PPDVASIL---ASGNWTPDSPSPAC-----------QCSQPGARRL-----------LPDCP 1385

  Fly   555 ------------------VNPKLGRVPVDFQHPVY------GYRNPNFTD------FAAPG---- 585
                              |....||...||....|      |.:...:.|      |:..|
  Rat  1386 AGAGGPPPPQAMAGFGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRYGGFSLGGRDPD 1450

  Fly   586 ------VILTIIFFLAVAVTSGAMLIDR------------------------------------- 607
                  |:.|:....|:........:||
  Rat  1451 LPSGREVVRTVAEMRALLSPQPGNTLDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRA 1515

  Fly   608 NEGMLERCLVAG----------ITGPEILLSQVVTQFTVMLSQTTFVLIVSFYF--------FEL 654
            |.|:|...|.:|          :..|..|..:.:::.|::.|....::.:...|        |.|
  Rat  1516 NNGLLRAFLPSGSVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTL 1580

  Fly   655 TLV-----------------------GN-IW----LVVALCILNGLCGMSFGFVISCAVDTERTA 691
            .|:                       || :|    .:||:||: .|..::|           :..
  Rat  1581 VLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIV-VLIFLAF-----------QQK 1633

  Fly   692 TYVA---MGSFLPIVMLCGIIWPIEG-MFPLLQFF----TAFLPLTKPTESMRSILQRGWGIDNP 748
            .|||   :.:.|.:::|.|  |.|.. |:|...||    ||::.||
  Rat  1634 AYVAPENLPALLLLLLLYG--WSITPLMYPASFFFSVPSTAYVVLT------------------- 1677

  Fly   749 VVYNGFISISSWVLVFLVLTIL 770
             ..|.||.|:|.:..| ||.:|
  Rat  1678 -CINLFIGINSSMATF-VLELL 1697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	72/226 (32%)
		CcmA	54..321	CDD:224054	88/363 (24%)
		ABC2_membrane_3	394..770	CDD:289468	93/522 (18%)
		ABC2_membrane	<581..738	CDD:279410	45/257 (18%)
Abca7	NP_997481.1	rim_protein	1..2127	CDD:130324	208/997 (21%)
		ABC2_membrane	<557..742	CDD:304374
		ABC_subfamily_A	805..1024	CDD:213230	72/226 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1086		7/41 (17%)
		ABC_subfamily_A	1818..2038	CDD:213230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2129..2170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900