DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33970 and Abca17

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001026807.1	Gene:	Abca17 / 287112	RGDID:	1560494	Length:	1773	Species:	Rattus norvegicus

Alignment Length:	752	Identity:	164/752 - (21%)
Similarity:	316/752 - (42%)	Gaps:	152/752 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 AVCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVL 111
            |:.::..:|::.:.::..:.:..|:|.:.||.|..|||.:|.||||:.|.:.|....:.|..::.
  Rat   524 AIEIQHLYKVFYTGRSKCIAVKDLSMNLYKGQITVLLGHNGAGKTTVCSVLTGLIPPSKGHAYIH 588

  Fly   112 GGRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLP-- 174
            |... |:........:|:.||...|:..||:.:.|.::|.:..:|..|..::.|.:|..|.|.
  Rat   589 GCEI-SKDMVRIRKNVGWCPQHDILFDNFTVTDHLYFYGQLKGLSHQDCHEKIEEMLHTLGLEDK 652

  Fly   175 --NASKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVI 237
              :.|||   ||||.:|::::.:||:...::|||||||.|:|...|::|||.|..  :.|..||:
  Rat   653 RNSRSKF---LSGGMKRKLAIGIALIAGSKVLILDEPTSGMDSSSRRAIWDLLQQ--QKGDRTVL 712

  Fly   238 ITTHYIDECAQAHMIG----LLRGGKMLAEESPDYLRQQYNA--------------DSLEDVF-- 282
            :|||::||   |.::|    :|..|::....:|.:|:|:|.|              :.|..|.
  Rat   713 LTTHFMDE---ADLLGDRIAILAKGELQCCGTPSFLKQKYGAGYYMTIIKTPLCDTEKLAKVIYH 774

  Fly   283 -LKLSVLQNMGKRRRSSIAQEIVEQVTVPAISNP---ALDMSDEQHAAEIS-GEFGDNIS----- 337
             :..::|:       |.|.:|::  .|:|..:.|   ||....||...|:. ..||.:::
  Rat   775 HIPNAILE-------SRIGEEMI--FTLPKKAMPRFEALFADLEQRQTELGISTFGASVTTMEEV 830

  Fly   338 ------MSSAARDPISTTAPAAPPLPPPQEIPTSFWYNLH------------------VMQSHHL 378
                  ::..:.:.::...|:...||....:|......||                  .:.....
  Rat   831 FIRVCKLADPSTNVLTEKRPSLRHLPRNHRVPVDRIKCLHSRIFSLSSDQPIRLNTGFSLLCQQF 895

  Fly   379 HALIWKNFLWMMRNVGVMLFI-VGLPVVQILL----FCYAIGH-DPTGLKLAVANHEMSGEMIME 437
            :|::.|...:..||..::|.: :.||:|.|:|    |.:.:.. |...|:|.:..:   |:.|:.
  Rat   896 YAMLLKKVAFSRRNWMLVLSVQILLPLVIIMLSLSFFNFKLRKLDNVPLELTLQTY---GQTIVP 957

  Fly   438 QFCPVHTGCNQTMLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAWAALVIQPNYTASLMER 502
            .|...::..: ..||..::.|||                      ......|.||.:....|:::
  Rat   958 FFIAENSRLD-PQLSDNFVKMLV----------------------AAGQVPLRIQGSVENFLLKK 999

  Fly   503 VE------DGRYAEDGTIE--SSDLAVRMDWSNQQ----------ISQLLYRDLQYTFFNFVGDM 549
            .:      |..|....:.|  :....|:..::||.          :..:|::.|.       |..
  Rat  1000 AKEAPEDFDKLYVVAASFEDVNDHTTVKALFNNQAYHSPSLALALVDNVLFKLLS-------GAN 1057

  Fly   550 LSDCDVNPKLGRVPVDFQHPVYGYRNPNFTDFAAPGVILTIIFFLAVAVTSGAMLI----DRNEG 610
            .|....|....:..::....:. |:.|.       |..|.:.|...:|..|.:..|    :::..
  Rat  1058 ASITTTNYPQPQTAMELSETIL-YQGPK-------GHYLVVNFLFGIAFLSSSFSILTVGEKSIK 1114

  Fly   611 MLERCLVAGITGPEILLSQVVTQFTVMLSQTTFVLIVSFYFFELTLV--GNIWLVVALCILNGLC 673
            ......::|::.....||.::......|..|..:::|.|::.|....  .:|..||.:.:|.|..
  Rat  1115 SKNLQFLSGVSMAAFWLSALLWDLISFLVPTLLLVLVFFWYKEEAFAHPQSIPAVVLIMMLYGWA 1179

  Fly   674 GMSFGFVISCAVDTERT--ATYVAMGSFL---PIVML 705
            .:...:.:|.:..|..:  ...|||.:||   |:|::
  Rat  1180 IIPLVYTVSFSFKTPGSGCVKLVAMLTFLSISPVVLV 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	70/229 (31%)
		CcmA	54..321	CDD:224054	85/294 (29%)
		ABC2_membrane_3	394..770	CDD:289468	63/347 (18%)
		ABC2_membrane	<581..738	CDD:279410	28/136 (21%)
Abca17	NP_001026807.1	ABC2_membrane_3	<262..464	CDD:289468
		ABC_subfamily_A	525..746	CDD:213230	70/229 (31%)
		drrA	543..834	CDD:130256	89/308 (29%)
		ABC2_membrane_3	913..1255	CDD:289468	63/345 (18%)
		CcmA	1369..1682	CDD:224054
		ABC_subfamily_A	1369..1590	CDD:213230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1690..1773
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900