DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and Abca5

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_775429.1	Gene:	Abca5 / 286970	RGDID:	628661	Length:	1642	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	90/353 - (25%)
Similarity:	162/353 - (45%)	Gaps:	34/353 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NSDLDLAARRRLFISQPSTLATRRQQAVCVRRAHKMYG-------SSKNPNVVLDGLNMTVPKGS 78
            :.|.|:.|.|..............:.|:.|...||.|.       |.|...|....::..|.||.
  Rat  1263 DEDEDVKAERLKVKELMGCQCCEEKPAIMVYNLHKEYDDKKDFLHSRKTTKVATKYVSFCVKKGE 1327

  Fly    79 IYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGS--GVPGPRIGYMPQEIALYGEFT 141
            |.||||.:|.||:|:::.:||.....||:|::  |..||..:  ......:||.||...|:.:.|
  Rat  1328 ILGLLGPNGAGKSTIINILVGDVEPTSGKIFL--GDYGSHSNEDDESTKCMGYCPQTNPLWPDIT 1390

  Fly   142 MRETLIYFGIISAMSKGDIEDRTEFLLKLLNL-PNASKFVKNLSGGQQRRVSLAVALLHEPELLI 205
            ::|....:|.:..||.||:::....:.|.|:| .:..|.||.|..|.:|::..|:::|..|::.:
  Rat  1391 LQEHFEIYGAVKGMSSGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQVTL 1455

  Fly   206 LDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDEC-AQAHMIGLLRGGKMLAEESPDYL 269
            ||||:.|:||..:|.:|..:....||.....::||||::|. |....:.::..|::....:..:|
  Rat  1456 LDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHL 1520

  Fly   270 RQQYNADSLEDVFLK-------LSVLQ--------NMGKRRR-SSIAQEIVEQVTVPAISNPALD 318
            :.::......::.||       :..||        |..::.. |||....:.:..|.::|.....
  Rat  1521 KSKFGKGYFLEIKLKDWIENLEIDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFAK 1585

  Fly   319 MSDEQHAAEISGEFGDNISMSSAARDPI 346
            :.:.:|...|     :..|.|.|..:.:
  Rat  1586 LEEAKHTFAI-----EEYSFSQATLEQV 1608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	69/232 (30%)
		CcmA	54..321	CDD:224054	79/293 (27%)
		ABC2_membrane_3	394..770	CDD:289468
		ABC2_membrane	<581..738	CDD:279410
Abca5	NP_775429.1	ABC2_membrane_3	<214..416	CDD:289468
		CcmA	476..788	CDD:224054
		ABC_subfamily_A	478..701	CDD:213230
		ABC2_membrane_3	<957..1224	CDD:289468
		CcmA	1288..1615	CDD:224054	86/328 (26%)
		ABC_subfamily_A	1290..1521	CDD:213230	69/232 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810