DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33970 and ABCA12

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_011509253.1	Gene:	ABCA12 / 26154	HGNCID:	14637	Length:	2598	Species:	Homo sapiens

Alignment Length:	977	Identity:	207/977 - (21%)
Similarity:	353/977 - (36%)	Gaps:	303/977 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TAPAATATTA----NSDLDLAARRRLFISQPSTLATRRQQAVCVRRAHKMYGSSKNPNVVLDGLN 71
            |.|:|:.|:.    :|:::         .:|..|..    .|.:....|:|||    .|.:|.||
Human  1321 TNPSASKTSPEYMFSSNIE---------PEPKDLTV----GVALHGVTKIYGS----KVAVDNLN 1368

  Fly    72 MTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRIGYMPQEIAL 136
            :...:|.|..|||.:|.||||.:|.:.|....::|.|:|. |:............:|...|...|
Human  1369 LNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVY-GKDIKTDLHTVRKNMGVCMQHDVL 1432

  Fly   137 YGEFTMRETLIYFGIISA--MSKGDIEDRTEFLLKLLNL-PNASKFVKNLSGGQQRRVSLAVALL 198
            :...|.:|.|:.:|.|..  .:|..:.:..:..||...| .:..|.|..||||.:|::|:::||:
Human  1433 FSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALI 1497

  Fly   199 HEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHT-TVIITTHYIDEC-AQAHMIGLLRGGKML 261
            ....::|||||:.||||..|:||||   .|:||... |:|::||::||. ..:..|..|..|.:.
Human  1498 GGSRVVILDEPSTGVDPCSRRSIWD---VISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLR 1559

  Fly   262 AEESPDYLRQQY----------------NADS--------------LEDVFLK------------ 284
            ...||.||::.:                ||::              |.:.:||
Human  1560 CCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLP 1624

  Fly   285 ----------LSVLQ----NMGKRR------RSSIAQEIVEQVTVPAISNPALDMS-------DE 322
                      ||:|:    .||...      ..:..:|:...:|..:..|.|:.:.       ..
Human  1625 PFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGN 1689

  Fly   323 QHAAEISGEFGDNISMSSA----ARDPISTTAPAAPPLPPPQEIPTSFWYNLH------VMQSHH 377
            .:|..||..  |::|:||:    ..|.|.|..          |....|...|.      :.:.||
Human  1690 SNANGISTP--DDLSVSSSNFTDRDDKILTRG----------ERLDGFGLLLKKIMAILIKRFHH 1742

  Fly   378 LHALIWKNFLWMMRNVGVMLFIV------GL----------PVVQILLFCYAIGHDPTGLKLAVA 426
            ... .||..:     ..|:|.||      ||          |.:||....|.......    ..|
Human  1743 TRR-NWKGLI-----AQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTA----FYA 1797

  Fly   427 NHEMSGEMI---MEQFCPVHTGCNQTMLSCRYLDMLVKNKSMVVQYVTDDE--------MAYEEV 480
            |:..|.|.:   |..|..:...|..|.      |:...||..:.::.|..|        ...|.|
Human  1798 NYHPSTEALVSAMWDFPGIDNMCLNTS------DLQCLNKDSLEKWNTSGEPITNFGVCSCSENV 1856

  Fly   481 RK----------GRAWAALVIQPNYTASLMERVEDGRYAEDGTIESSDLAVRMDWSNQQISQLLY 535
            ::          .|.:::.||. |.|         |:..|:..|.:::..|:..:........|.
Human  1857 QECPKFNYSPPHRRTYSSQVIY-NLT---------GQRVENYLISTANEFVQKRYGGWSFGLPLT 1911

  Fly   536 RDLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQ--HPVYGYRNP--NFT--------DFAAPGVI- 587
            :||::.        ::....|..|.:|..|.:  |.:..|.|.  ||.        |.|..|:|
Human  1912 KDLRFD--------ITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIM 1968

  Fly   588 -------------------------LTIIFFLAVAVTSGAMLIDRNEGMLERCL--VAGITGPEI 625
                                     |:|:...:|...|....:.|......:.|  ::||.
Human  1969 YSHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIG---- 2029

  Fly   626 LLSQVVTQFTVMLSQTTFVLIVSFYF----FELTLV-----------GNIWLVVALCILNGLCGM 675
                 ||.:.|    |.|:..:.||.    |.:.::           .|:..|..|.:|.|....
Human  2030 -----VTCYWV----TNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATF 2085

  Fly   676 SFGFVISCAVDTERTA--TYVAMGSFLPI--VMLCGIIWPIEG--------------------MF 716
            |:.::::........|  |||.:..|..|  ::...:::.:..                    :|
Human  2086 SWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIF 2150

  Fly   717 PLLQFFTAFLPLTKPTESMRSILQ--RGWGIDNPVVYNG----------FISISSWVLVFLVLTI 769
            |...|....:.|::    .:|:|.  :.:|::.|   |.          |:::.|...:|..|.:
Human  2151 PQFCFGYGLIELSQ----QQSVLDFLKAYGVEYP---NETFEMNKLGAMFVALVSQGTMFFSLRL 2208

  Fly   770 LL 771
            |:
Human  2209 LI 2210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	76/226 (34%)
		CcmA	54..321	CDD:224054	90/340 (26%)
		ABC2_membrane_3	394..770	CDD:289468	91/503 (18%)
		ABC2_membrane	<581..738	CDD:279410	35/223 (16%)
ABCA12	XP_011509253.1	ABC2_membrane_3	<1026..1270	CDD:289468
		ZnuC	1349..1573	CDD:224046	77/231 (33%)
		ABC_subfamily_A	1353..1568	CDD:213230	75/222 (34%)
		ABC2_membrane_3	<1916..2177	CDD:289468	47/285 (16%)
		ABC_subfamily_A	2257..2480	CDD:213230
		CcmA	2262..2570	CDD:224054
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810