DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33970 and ABCA4

DIOPT Version :9

Sequence 1:NP_001034071.1 Gene:CG33970 / 43186 FlyBaseID:FBgn0053970 Length:777 Species:Drosophila melanogaster
Sequence 2:NP_000341.2 Gene:ABCA4 / 24 HGNCID:34 Length:2273 Species:Homo sapiens


Alignment Length:952 Identity:194/952 - (20%)
Similarity:336/952 - (35%) Gaps:300/952 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 VCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLG 112
            |||:...|::.....|.|  |.||:|..:..|...||.:|.||||.||.:.|.....||.: ::|
Human   929 VCVKNLVKIFEPCGRPAV--DRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTV-LVG 990

  Fly   113 GRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLPN-A 176
            ||............:|..||...|:...|:.|.::::..:...|:.:.:...|.:|:...|.: .
Human   991 GRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKR 1055

  Fly   177 SKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTH 241
            ::..::||||.||::|:|:|.:.:.:::||||||.||||..|:||||.|:.. ::|. |:|::||
Human  1056 NEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKY-RSGR-TIIMSTH 1118

  Fly   242 YIDECAQAHMIG----LLRGGKMLAEESPDYLRQQY----------------------------- 273
            ::||   |.::|    ::..|::....:|.:|:..:                             
Human  1119 HMDE---ADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCS 1180

  Fly   274 -----------------------NADSLEDVFL--------------KLSVL---QNMGKRRRSS 298
                                   :.:.|.||.|              :|..|   :|...|..:|
Human  1181 SKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYAS 1245

  Fly   299 IAQEIVE----------------------QVTVPAISNPALDMSDEQHAAEISGE---FGDNISM 338
            :.:|:.|                      :||..:.|.|......:|....::..   .|.....
Human  1246 LFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKA 1310

  Fly   339 SSAARDP--ISTTAPAAPP--LPPPQ-EIP-------TSFWYNLHVMQSHHLHALIWKNFLWMMR 391
            ....:|.  .|..||||.|  .|||: |.|       |..     |:|  |:.||:.|.|...:|
Human  1311 GQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQL-----VLQ--HVQALLVKRFQHTIR 1368

  Fly   392 NVGVMLFIVGLPVVQILL-FCYAIGHDPTGLKLAVANHE-MSGEMI---------MEQFCPVHTG 445
            :....|..:.||...:.| ...:|...|.|...|:..|. :.|:..         .|||      
Human  1369 SHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQF------ 1427

  Fly   446 CNQTMLSCRYLDMLVKNKSMVVQYVTDDEMAYEEVRKGRAWAALVIQPNYT-------------- 496
               |:|:    |:|:.......:.:.:..:..........|....:.||.|              
Human  1428 ---TVLA----DVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPS 1485

  Fly   497 ----ASLMERV---------EDGRYAEDGTIESSDLAVRMDWSNQQISQLLYR------------ 536
                .|..|::         ..|......|..|::  :..|.:::.||..|.:            
Human  1486 PSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTE--ILQDLTDRNISDFLVKTYPALIRSSLKS 1548

  Fly   537 -----DLQYTFFNFVGDM-------------LSDCDVNPKLGRVPVDFQHPVYGYRNPNFTDF-- 581
                 :.:|...:..|.:             |||      |||:......|:....:....||  
Human  1549 KFWVNEQRYGGISIGGKLPVVPITGEALVGFLSD------LGRIMNVSGGPITREASKEIPDFLK 1607

  Fly   582 ---AAPGVIL--------TIIFFLAV---AVTSGAMLIDRNEGMLERCLVAGITGPEILLSQVVT 632
               ....:.:        .::.||.|   |:...::..||:.   |...:..|:.|..|..:.::
Human  1608 HLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSP---EEYGITVISQPLNLTKEQLS 1669

  Fly   633 QFTVMLSQTTFVLIVSFYF--------FELTLVGN------------------------IWLVVA 665
            :.||:.:....|:.:...|        |.|.|:..                        :|.::.
Human  1670 EITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMN 1734

  Fly   666 LCILNGL-CGMSFGFVISCAVDTERTATYVAMGSFLPIVMLCGIIWP-IEGMFPLLQFF----TA 724
            ..:..|| .|:..||........|.....||      :::|.|  |. |..|:|....|    ||
Human  1735 YSVSAGLVVGIFIGFQKKAYTSPENLPALVA------LLLLYG--WAVIPMMYPASFLFDVPSTA 1791

  Fly   725 FLPLTKPTESMRSILQRGWGIDNPVVYNGFISISSWVLVFLV 766
            ::.|:                    ..|.||.|:|..:.|::
Human  1792 YVALS--------------------CANLFIGINSSAITFIL 1813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33970NP_001034071.1 P-loop_NTPase 48..270 CDD:304359 72/226 (32%)
CcmA 54..321 CDD:224054 85/362 (23%)
ABC2_membrane_3 394..770 CDD:289468 83/495 (17%)
ABC2_membrane <581..738 CDD:279410 37/210 (18%)
ABCA4NP_000341.2 rim_protein 1..2272 CDD:130324 194/952 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..911
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1345 15/60 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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