DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and ABCA3

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001080.2	Gene:	ABCA3 / 21	HGNCID:	33	Length:	1704	Species:	Homo sapiens

Alignment Length:	291	Identity:	93/291 - (31%)
Similarity:	152/291 - (52%)	Gaps:	29/291 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DLDLA-ARRRLFISQPSTLATRRQQAVCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLLGAS 86
            |.|:| .|.|:....|.:|.   ...:.::...|:| ..:.|.:.:|.|::.|.||..:||||.:
Human  1358 DQDVADERTRILAPSPDSLL---HTPLIIKELSKVY-EQRVPLLAVDRLSLAVQKGECFGLLGFN 1418

  Fly    87 GCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRIGYMPQEIALYGEFTMRETLIYFGI 151
            |.||||....:.|...|.||:.:| ||...|...|....||||.||..||....|.||.|:.:..
Human  1419 GAGKTTTFKMLTGEESLTSGDAFV-GGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYAR 1482

  Fly   152 ISAMSKGDIEDRTEFLLK-LLNLPNASKFVKNLSGGQQRRVSLAVALLHEPELLILDEPTVGVDP 215
            :..:.:..|....|..|: ||..|:|:|.|:..|||.:|::|..:||:.||.::.||||:.|:||
Human  1483 LRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDP 1547

  Fly   216 VLRQSIWDHLVDITKNGHTTVIITTHYIDEC-AQAHMIGLLRGGKMLAEESPDYLRQQYNA---- 275
            |.|:.:||.:....::| ..:|||:|.::|| |....:.::..|:.....||.:|:.::.:
Human  1548 VARRLLWDTVARARESG-KAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611

  Fly   276 ----------DSLED--VFLKL----SVLQN 290
                      ::||:  .|:.|    |||::
Human  1612 RAKVQSEGQQEALEEFKAFVDLTFPGSVLED 1642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	78/223 (35%)
		CcmA	54..321	CDD:224054	86/259 (33%)
		ABC2_membrane_3	394..770	CDD:289468
		ABC2_membrane	<581..738	CDD:279410
ABCA3	NP_001080.2	ABC2_membrane_3	<271..469	CDD:289468
		CcmA	530..839	CDD:224054
		ABC_subfamily_A	530..751	CDD:213230
		ABC2_membrane_3	923..1261	CDD:289468
		ABC_subfamily_A	1381..1602	CDD:213230	78/223 (35%)
		drrA	1397..1692	CDD:130256	83/248 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810