DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and ABCA2

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_997698.1	Gene:	ABCA2 / 20	HGNCID:	32	Length:	2466	Species:	Homo sapiens

Alignment Length:	401	Identity:	105/401 - (26%)
Similarity:	175/401 - (43%)	Gaps:	65/401 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PPTAPAATATTANSDLDLAARRRLFISQPSTLATRRQQAVCVRRAHKMYGSSKNPNVV-LDGLNM 72
            |...|.:| .....|:|:|:.|:..:...:.     ...|.:....|:|.|.|...:: :|.|.:
Human  2048 PQRMPVST-KPVEDDVDVASERQRVLRGDAD-----NDMVKIENLTKVYKSRKIGRILAVDRLCL 2106

  Fly    73 TVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGV------PGPRIGYMP 131
            .|..|..:||||.:|.|||:....:.|......||.:|       .|..|      ....:||.|
Human  2107 GVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFV-------NGHSVLKELLQVQQSLGYCP 2164

  Fly   132 QEIALYGEFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNLPN-ASKFVKNLSGGQQRRVSLAV 195
            |..||:.|.|.||.|..:..:..:|..|.....::.|:.|.|.. |.|.....|||.:|::|.|:
Human  2165 QCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAI 2229

  Fly   196 ALLHEPELLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDEC-AQAHMIGLLRGGK 259
            ||:..|..:.|||||.|:||..|:.:|:.::|:.|.|. :|::|:|.::|| |....:.::..|:
Human  2230 ALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGR-SVVLTSHSMEECEALCTRLAIMVNGR 2293

  Fly   260 MLAEESPDYLRQQY-----------NADSLEDV--FLKLSVLQNMGKRRRS------------SI 299
            :....|..:|:.::           ::.|::||  |...:..:.|.|.|..            |:
Human  2294 LRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISL 2358

  Fly   300 AQEI--VEQVTVP------AISNPALDMSDEQHAAEISGEFGDNISMS-----SAARDPISTTAP 351
            ||..  :|||:..      ::|...||......|.:.|    ||:...     ||.:.|:.....
Human  2359 AQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQS----DNLEQQETEPPSALQSPLGCLLS 2419

  Fly   352 AAPPLPPPQEI 362
            ...|...|.|:
Human  2420 LLRPRSAPTEL 2430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	71/230 (31%)
		CcmA	54..321	CDD:224054	87/308 (28%)
		ABC2_membrane_3	394..770	CDD:289468
		ABC2_membrane	<581..738	CDD:279410
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	97/367 (26%)
		ABC_subfamily_A	1021..1240	CDD:213230
		ABC_subfamily_A	2081..2304	CDD:213230	71/230 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810