DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33970 and abt-2

DIOPT Version :9

Sequence 1:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_490949.3	Gene:	abt-2 / 171782	WormBaseID:	WBGene00000020	Length:	2146	Species:	Caenorhabditis elegans

Alignment Length:	367	Identity:	100/367 - (27%)
Similarity:	166/367 - (45%)	Gaps:	67/367 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LFISQPST-----LATRRQQ------------AVCVRRAHKMYGSSKNPNVV-LDGLNMTVPKGS 78
            :.:.:|||     :...||:            |:.||...|.|    ||.:: :.|::..|..|.
Worm  1769 MMLREPSTCDDEDVVKERQRVDAIPMDSSDNHALIVRNLAKAY----NPELLAVKGISFAVEPGE 1829

  Fly    79 IYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGR--PGSRGSGVPGPRIGYMPQEIALYGEFT 141
            .:||||.:|.||||..:.:..:.|...|.|.:...|  .||........::||.||..||..:.:
Worm  1830 CFGLLGLNGAGKTTTFAMLTAKIRPGHGSIEMQNTRINTGSFSDVRNFQQLGYCPQFDALNMKLS 1894

  Fly   142 MRETLIYFGIISAMSKGDIEDRTEFLLKLLNL-PNASKFVKNLSGGQQRRVSLAVALLHEPELLI 205
            .||.|.::..|..:....|:...:.||..|:| |.|:....:||||.:|::|:||||:.:|.|:.
Worm  1895 TRENLKFYARIRGIVPTQIDSIIDRLLIALHLRPYANTQTSSLSGGNRRKLSVAVALVSQPSLIF 1959

  Fly   206 LDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDEC-AQAHMIGLLRGGKMLAEESPDYL 269
            ||||:.|:||..:|.:|..:..:.|:| ..|::|:|.::|| |....|.::..|::.......:|
Worm  1960 LDEPSAGMDPGSQQFLWKVIERLCKSG-KAVVLTSHSMEECEALCTRIAIMDRGRIRCLGGKQHL 2023

  Fly   270 RQQYNADSLEDVFLKLSVLQNMGKRRRSSIAQEIV--------EQVTVPAISNPALDMSDEQHAA 326
            :.:|...|:        :...|||...   |:||.        :...|.||....:.:..||..|
Worm  2024 KSKYGKGSM--------LTMKMGKDEN---AKEIAGIMRSKLGDGSRVEAIHCSTIFIHIEQGTA 2077

  Fly   327 EIS---------------GEFG------DNISMSSAARDPIS 347
            .::               .:|.      ||:..|.|..|.:|
Worm  2078 SVARVLEIVNQVKKMYDVDDFTLTQSTLDNVFQSIAESDNLS 2119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	72/226 (32%)
		CcmA	54..321	CDD:224054	82/279 (29%)
		ABC2_membrane_3	394..770	CDD:289468
		ABC2_membrane	<581..738	CDD:279410
abt-2	NP_490949.3	rim_protein	39..2117	CDD:130324	98/363 (27%)
		ABC_subfamily_A	929..1134	CDD:213230
		ABC_subfamily_A	1802..2024	CDD:213230	72/226 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810